Search Results
Overview
| Uniprot ID | P12081 |
|---|---|
| Protein Name | Histidine--tRNA ligase, cytoplasmic |
| Gene Name | HARS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 418 | VLVASAQKKLLEERL |
| 419 | LVASAQKKLLEERLK |
| 42 | VAKLLKLKAQLGPDE |
| 443 | IKAELLYKKNPKLLN |
| 444 | KAELLYKKNPKLLNQ |
Function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516)
Protein Sequence
10
MAERAALEEL
20
VKLQGERVRG
30
LKQQKASAEL
40
IEEEVAKLLK
50
LKAQLGPDES
60
KQKFVLKTPK
70
GTRDYSPRQM
80
AVREKVFDVI
90
IRCFKRHGAE
100
VIDTPVFELK
110
ETLMGKYGED
120
SKLIYDLKDQ
130
GGELLSLRYD
140
LTVPFARYLA
150
MNKLTNIKRY
160
HIAKVYRRDN
170
PAMTRGRYRE
180
FYQCDFDIAG
190
NFDPMIPDAE
200
CLKIMCEILS
210
SLQIGDFLVK
220
VNDRRILDGM
230
FAICGVSDSK
240
FRTICSSVDK
250
LDKVSWEEVK
260
NEMVGEKGLA
270
PEVADRIGDY
280
VQQHGGVSLV
290
EQLLQDPKLS
300
QNKQALEGLG
310
DLKLLFEYLT
320
LFGIDDKISF
330
DLSLARGLDY
340
YTGVIYEAVL
350
LQTPAQAGEE
360
PLGVGSVAAG
370
GRYDGLVGMF
380
DPKGRKVPCV
390
GLSIGVERIF
400
SIVEQRLEAL
410
EEKIRTTETQ
420
VLVASAQKKL
430
LEERLKLVSE
440
LWDAGIKAEL
450
LYKKNPKLLN
460
QLQYCEEAGI
470
PLVAIIGEQE
480
LKDGVIKLRS
490
VTSREEVDVR
500
REDLVEEIKR
RTGQPLCIC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004821 | histidine-tRNA ligase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006427 | histidyl-tRNA aminoacylation |
| Biological Process | GO:0006412 | translation |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.