Search Results

Overview

Uniprot IDP12109
Protein NameCollagen alpha-1(VI) chain
Gene NameCOL6A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
114 PGGRDALKSSVDAVK
121 KSSVDAVKYFGKGTY
125 DAVKYFGKGTYTDCA
135 YTDCAIKKGLEQLLV
148 LVGGSHLKENKYLIV
166 GHPLEGYKEPCGGLE
180 EDAVNEAKHLGVKVF
53 ESVALRLKPYGALVD
61 PYGALVDKVKSFTKR
640 IAKDFVVKVIDRLSR
688 IRNVQELKEAIKSLQ
936 EASSGAAKKRLLLFS
957 ATPAAIEKAVQEAQR
990 IRVLVTGKTAEYDVA

Function

Collagen VI acts as a cell-binding protein

Protein Sequence

10 MRAARALLPL 20 LLQACWTAAQ 30 DEPETPRAVA 40 FQDCPVDLFF 50 VLDTSESVAL 60 RLKPYGALVD 70 KVKSFTKRFI 80 DNLRDRYYRC 90 DRNLVWNAGA 100 LHYSDEVEII 110 QGLTRMPGGR 120 DALKSSVDAV 130 KYFGKGTYTD 140 CAIKKGLEQL 150 LVGGSHLKEN 160 KYLIVVTDGH 170 PLEGYKEPCG 180 GLEDAVNEAK 190 HLGVKVFSVA 200 ITPDHLEPRL 210 SIIATDHTYR 220 RNFTAADWGQ 230 SRDAEEAISQ 240 TIDTIVDMIK 250 NNVEQVCCSF 260 ECQPARGPPG 270 LRGDPGFEGE 280 RGKPGLPGEK 290 GEAGDPGRPG 300 DLGPVGYQGM 310 KGEKGSRGEK 320 GSRGPKGYKG 330 EKGKRGIDGV 340 DGVKGEMGYP 350 GLPGCKGSPG 360 FDGIQGPPGP 370 KGDPGAFGLK 380 GEKGEPGADG 390 EAGRPGSSGP 400 SGDEGQPGEP 410 GPPGEKGEAG 420 DEGNPGPDGA 430 PGERGGPGER 440 GPRGTPGTRG 450 PRGDPGEAGP 460 QGDQGREGPV 470 GVPGDPGEAG 480 PIGPKGYRGD 490 EGPPGSEGAR 500 GAPGPAGPPG 510 DPGLMGERGE 520 DGPAGNGTEG 530 FPGFPGYPGN 540 RGAPGINGTK 550 GYPGLKGDEG 560 EAGDPGDDNN 570 DIAPRGVKGA 580 KGYRGPEGPQ 590 GPPGHQGPPG 600 PDECEILDII 610 MKMCSCCECK 620 CGPIDLLFVL 630 DSSESIGLQN 640 FEIAKDFVVK 650 VIDRLSRDEL 660 VKFEPGQSYA 670 GVVQYSHSQM 680 QEHVSLRSPS 690 IRNVQELKEA 700 IKSLQWMAGG 710 TFTGEALQYT 720 RDQLLPPSPN 730 NRIALVITDG 740 RSDTQRDTTP 750 LNVLCSPGIQ 760 VVSVGIKDVF 770 DFIPGSDQLN 780 VISCQGLAPS 790 QGRPGLSLVK 800 ENYAELLEDA 810 FLKNVTAQIC 820 IDKKCPDYTC 830 PITFSSPADI 840 TILLDGSASV 850 GSHNFDTTKR 860 FAKRLAERFL 870 TAGRTDPAHD 880 VRVAVVQYSG 890 TGQQRPERAS 900 LQFLQNYTAL 910 ASAVDAMDFI 920 NDATDVNDAL 930 GYVTRFYREA 940 SSGAAKKRLL 950 LFSDGNSQGA 960 TPAAIEKAVQ 970 EAQRAGIEIF 980 VVVVGRQVNE 990 PHIRVLVTGK 1000 TAEYDVAYGE 1010 SHLFRVPSYQ 1020 ALLRGVFHQT VSRKVALG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005589 collagen type VI trimer
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0097708 intracellular vesicle
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0001527 microfibril
Cellular Component GO:0030016 myofibril
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0016529 sarcoplasmic reticulum
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0030020 extracellular matrix structural constituent conferring tensile strength
Molecular Function GO:0048407 platelet-derived growth factor binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0048741 skeletal muscle fiber development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.