Search Results

Overview

Uniprot IDP12110
Protein NameCollagen alpha-2(VI) chain
Gene NameCOL6A2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1000 RAAVFHEKDYDSLAQ
120 SDRASFIKNLQGISS
197 VAPNQNLKEQGLRDI
239 NRIIKVMKHEAYGEC
650 NRLGAIAKDPKSETG
653 GAIAKDPKSETGTRV
688 IDSLSSFKEAVKNLE
766 IGDMFHEKHESENLY
779 LYSIACDKPQQVRNM
851 LGEQNFHKARRFVEQ

Function

Collagen VI acts as a cell-binding protein

Protein Sequence

10 MLQGTCSVLL 20 LWGILGAIQA 30 QQQEVISPDT 40 TERNNNCPEK 50 TDCPIHVYFV 60 LDTSESVTMQ 70 SPTDILLFHM 80 KQFVPQFISQ 90 LQNEFYLDQV 100 ALSWRYGGLH 110 FSDQVEVFSP 120 PGSDRASFIK 130 NLQGISSFRR 140 GTFTDCALAN 150 MTEQIRQDRS 160 KGTVHFAVVI 170 TDGHVTGSPC 180 GGIKLQAERA 190 REEGIRLFAV 200 APNQNLKEQG 210 LRDIASTPHE 220 LYRNDYATML 230 PDSTEIDQDT 240 INRIIKVMKH 250 EAYGECYKVS 260 CLEIPGPSGP 270 KGYRGQKGAK 280 GNMGEPGEPG 290 QKGRQGDPGI 300 EGPIGFPGPK 310 GVPGFKGEKG 320 EFGADGRKGA 330 PGLAGKNGTD 340 GQKGKLGRIG 350 PPGCKGDPGN 360 RGPDGYPGEA 370 GSPGERGDQG 380 GKGDPGRPGR 390 RGPPGEIGAK 400 GSKGYQGNSG 410 APGSPGVKGA 420 KGGPGPRGPK 430 GEPGRRGDPG 440 TKGSPGSDGP 450 KGEKGDPGPE 460 GPRGLAGEVG 470 NKGAKGDRGL 480 PGPRGPQGAL 490 GEPGKQGSRG 500 DPGDAGPRGD 510 SGQPGPKGDP 520 GRPGFSYPGP 530 RGAPGEKGEP 540 GPRGPEGGRG 550 DFGLKGEPGR 560 KGEKGEPADP 570 GPPGEPGPRG 580 PRGVPGPEGE 590 PGPPGDPGLT 600 ECDVMTYVRE 610 TCGCCDCEKR 620 CGALDVVFVI 630 DSSESIGYTN 640 FTLEKNFVIN 650 VVNRLGAIAK 660 DPKSETGTRV 670 GVVQYSHEGT 680 FEAIQLDDER 690 IDSLSSFKEA 700 VKNLEWIAGG 710 TWTPSALKFA 720 YDRLIKESRR 730 QKTRVFAVVI 740 TDGRHDPRDD 750 DLNLRALCDR 760 DVTVTAIGIG 770 DMFHEKHESE 780 NLYSIACDKP 790 QQVRNMTLFS 800 DLVAEKFIDD 810 MEDVLCPDPQ 820 IVCPDLPCQT 830 ELSVAQCTQR 840 PVDIVFLLDG 850 SERLGEQNFH 860 KARRFVEQVA 870 RRLTLARRDD 880 DPLNARVALL 890 QFGGPGEQQV 900 AFPLSHNLTA 910 IHEALETTQY 920 LNSFSHVGAG 930 VVHAINAIVR 940 SPRGGARRHA 950 ELSFVFLTDG 960 VTGNDSLHES 970 AHSMRKQNVV 980 PTVLALGSDV 990 DMDVLTTLSL 1000 GDRAAVFHEK 1010 DYDSLAQPGF FDRFIRWIC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005589 collagen type VI trimer
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0001527 microfibril
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0030020 extracellular matrix structural constituent conferring tensile strength
Biological Process GO:0007155 cell adhesion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.