Search Results

Overview

Uniprot IDP12259
Protein NameCoagulation factor V
Gene NameF5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
205 LTEGGTQKTFDKQIV

Function

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin

Protein Sequence

10 MFPGCPRLWV 20 LVVLGTSWVG 30 WGSQGTEAAQ 40 LRQFYVAAQG 50 ISWSYRPEPT 60 NSSLNLSVTS 70 FKKIVYREYE 80 PYFKKEKPQS 90 TISGLLGPTL 100 YAEVGDIIKV 110 HFKNKADKPL 120 SIHPQGIRYS 130 KLSEGASYLD 140 HTFPAEKMDD 150 AVAPGREYTY 160 EWSISEDSGP 170 THDDPPCLTH 180 IYYSHENLIE 190 DFNSGLIGPL 200 LICKKGTLTE 210 GGTQKTFDKQ 220 IVLLFAVFDE 230 SKSWSQSSSL 240 MYTVNGYVNG 250 TMPDITVCAH 260 DHISWHLLGM 270 SSGPELFSIH 280 FNGQVLEQNH 290 HKVSAITLVS 300 ATSTTANMTV 310 GPEGKWIISS 320 LTPKHLQAGM 330 QAYIDIKNCP 340 KKTRNLKKIT 350 REQRRHMKRW 360 EYFIAAEEVI 370 WDYAPVIPAN 380 MDKKYRSQHL 390 DNFSNQIGKH 400 YKKVMYTQYE 410 DESFTKHTVN 420 PNMKEDGILG 430 PIIRAQVRDT 440 LKIVFKNMAS 450 RPYSIYPHGV 460 TFSPYEDEVN 470 SSFTSGRNNT 480 MIRAVQPGET 490 YTYKWNILEF 500 DEPTENDAQC 510 LTRPYYSDVD 520 IMRDIASGLI 530 GLLLICKSRS 540 LDRRGIQRAA 550 DIEQQAVFAV 560 FDENKSWYLE 570 DNINKFCENP 580 DEVKRDDPKF 590 YESNIMSTIN 600 GYVPESITTL 610 GFCFDDTVQW 620 HFCSVGTQNE 630 ILTIHFTGHS 640 FIYGKRHEDT 650 LTLFPMRGES 660 VTVTMDNVGT 670 WMLTSMNSSP 680 RSKKLRLKFR 690 DVKCIPDDDE 700 DSYEIFEPPE 710 STVMATRKMH 720 DRLEPEDEES 730 DADYDYQNRL 740 AAALGIRSFR 750 NSSLNQEEEE 760 FNLTALALEN 770 GTEFVSSNTD 780 IIVGSNYSSP 790 SNISKFTVNN 800 LAEPQKAPSH 810 QQATTAGSPL 820 RHLIGKNSVL 830 NSSTAEHSSP 840 YSEDPIEDPL 850 QPDVTGIRLL 860 SLGAGEFKSQ 870 EHAKHKGPKV 880 ERDQAAKHRF 890 SWMKLLAHKV 900 GRHLSQDTGS 910 PSGMRPWEDL 920 PSQDTGSPSR 930 MRPWKDPPSD 940 LLLLKQSNSS 950 KILVGRWHLA 960 SEKGSYEIIQ 970 DTDEDTAVNN 980 WLISPQNASR 990 AWGESTPLAN 1000 KPGKQSGHPK 1010 FPRVRHKSLQ 1020 VRQDGGKSRL 1030 KKSQFLIKTR 1040 KKKKEKHTHH 1050 APLSPRTFHP 1060 LRSEAYNTFS 1070 ERRLKHSLVL 1080 HKSNETSLPT 1090 DLNQTLPSMD 1100 FGWIASLPDH 1110 NQNSSNDTGQ 1120 ASCPPGLYQT 1130 VPPEEHYQTF 1140 PIQDPDQMHS 1150 TSDPSHRSSS 1160 PELSEMLEYD 1170 RSHKSFPTDI 1180 SQMSPSSEHE 1190 VWQTVISPDL 1200 SQVTLSPELS 1210 QTNLSPDLSH 1220 TTLSPELIQR 1230 NLSPALGQMP 1240 ISPDLSHTTL 1250 SPDLSHTTLS 1260 LDLSQTNLSP 1270 ELSQTNLSPA 1280 LGQMPLSPDL 1290 SHTTLSLDFS 1300 QTNLSPELSH 1310 MTLSPELSQT 1320 NLSPALGQMP 1330 ISPDLSHTTL 1340 SLDFSQTNLS 1350 PELSQTNLSP 1360 ALGQMPLSPD 1370 PSHTTLSLDL 1380 SQTNLSPELS 1390 QTNLSPDLSE 1400 MPLFADLSQI 1410 PLTPDLDQMT 1420 LSPDLGETDL 1430 SPNFGQMSLS 1440 PDLSQVTLSP 1450 DISDTTLLPD 1460 LSQISPPPDL 1470 DQIFYPSESS 1480 QSLLLQEFNE 1490 SFPYPDLGQM 1500 PSPSSPTLND 1510 TFLSKEFNPL 1520 VIVGLSKDGT 1530 DYIEIIPKEE 1540 VQSSEDDYAE 1550 IDYVPYDDPY 1560 KTDVRTNINS 1570 SRDPDNIAAW 1580 YLRSNNGNRR 1590 NYYIAAEEIS 1600 WDYSEFVQRE 1610 TDIEDSDDIP 1620 EDTTYKKVVF 1630 RKYLDSTFTK 1640 RDPRGEYEEH 1650 LGILGPIIRA 1660 EVDDVIQVRF 1670 KNLASRPYSL 1680 HAHGLSYEKS 1690 SEGKTYEDDS 1700 PEWFKEDNAV 1710 QPNSSYTYVW 1720 HATERSGPES 1730 PGSACRAWAY 1740 YSAVNPEKDI 1750 HSGLIGPLLI 1760 CQKGILHKDS 1770 NMPMDMREFV 1780 LLFMTFDEKK 1790 SWYYEKKSRS 1800 SWRLTSSEMK 1810 KSHEFHAING 1820 MIYSLPGLKM 1830 YEQEWVRLHL 1840 LNIGGSQDIH 1850 VVHFHGQTLL 1860 ENGNKQHQLG 1870 VWPLLPGSFK 1880 TLEMKASKPG 1890 WWLLNTEVGE 1900 NQRAGMQTPF 1910 LIMDRDCRMP 1920 MGLSTGIISD 1930 SQIKASEFLG 1940 YWEPRLARLN 1950 NGGSYNAWSV 1960 EKLAAEFASK 1970 PWIQVDMQKE 1980 VIITGIQTQG 1990 AKHYLKSCYT 2000 TEFYVAYSSN 2010 QINWQIFKGN 2020 STRNVMYFNG 2030 NSDASTIKEN 2040 QFDPPIVARY 2050 IRISPTRAYN 2060 RPTLRLELQG 2070 CEVNGCSTPL 2080 GMENGKIENK 2090 QITASSFKKS 2100 WWGDYWEPFR 2110 ARLNAQGRVN 2120 AWQAKANNNK 2130 QWLEIDLLKI 2140 KKITAIITQG 2150 CKSLSSEMYV 2160 KSYTIHYSEQ 2170 GVEWKPYRLK 2180 SSMVDKIFEG 2190 NTNTKGHVKN 2200 FFNPPIISRF 2210 IRVIPKTWNQ 2220 SIALRLELFG CDIY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030134 COPII-coated ER to Golgi transport vesicle
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031091 platelet alpha granule
Cellular Component GO:0031093 platelet alpha granule lumen
Molecular Function GO:0005507 copper ion binding
Biological Process GO:0008015 blood circulation
Biological Process GO:0007596 blood coagulation
Biological Process GO:0032571 response to vitamin K

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.