Search Results

Overview

Uniprot IDP12268
Protein NameInosine-5'-monophosphate dehydrogenase 2
Gene NameIMPDH2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
238 RDYPLASKDAKKQLL
242 LASKDAKKQLLCGAA
422 GSLDAMDKHLSSQNR
436 RYFSEADKIKVAQGV
438 FSEADKIKVAQGVSG
450 VSGAVQDKGSIHKFV
511 HSLHSYEKRLF****

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors

Protein Sequence

10 MADYLISGGT 20 SYVPDDGLTA 30 QQLFNCGDGL 40 TYNDFLILPG 50 YIDFTADQVD 60 LTSALTKKIT 70 LKTPLVSSPM 80 DTVTEAGMAI 90 AMALTGGIGF 100 IHHNCTPEFQ 110 ANEVRKVKKY 120 EQGFITDPVV 130 LSPKDRVRDV 140 FEAKARHGFC 150 GIPITDTGRM 160 GSRLVGIISS 170 RDIDFLKEEE 180 HDCFLEEIMT 190 KREDLVVAPA 200 GITLKEANEI 210 LQRSKKGKLP 220 IVNEDDELVA 230 IIARTDLKKN 240 RDYPLASKDA 250 KKQLLCGAAI 260 GTHEDDKYRL 270 DLLAQAGVDV 280 VVLDSSQGNS 290 IFQINMIKYI 300 KDKYPNLQVI 310 GGNVVTAAQA 320 KNLIDAGVDA 330 LRVGMGSGSI 340 CITQEVLACG 350 RPQATAVYKV 360 SEYARRFGVP 370 VIADGGIQNV 380 GHIAKALALG 390 ASTVMMGSLL 400 AATTEAPGEY 410 FFSDGIRLKK 420 YRGMGSLDAM 430 DKHLSSQNRY 440 FSEADKIKVA 450 QGVSGAVQDK 460 GSIHKFVPYL 470 IAGIQHSCQD 480 IGAKSLTQVR 490 AMMYSGELKF 500 EKRTSSAQVE 510 GGVHSLHSYE KRLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003938 IMP dehydrogenase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0097294 'de novo' XMP biosynthetic process
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0006177 GMP biosynthetic process
Biological Process GO:0006183 GTP biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.