Search Results
Overview
| Uniprot ID | P12314 |
|---|---|
| Protein Name | High affinity immunoglobulin gamma Fc receptor I |
| Gene Name | FCGR1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 336 | LDSGHEKKVISSLQE |
Function
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells
Protein Sequence
10
MWFLTTLLLW
20
VPVDGQVDTT
30
KAVITLQPPW
40
VSVFQEETVT
50
LHCEVLHLPG
60
SSSTQWFLNG
70
TATQTSTPSY
80
RITSASVNDS
90
GEYRCQRGLS
100
GRSDPIQLEI
110
HRGWLLLQVS
120
SRVFTEGEPL
130
ALRCHAWKDK
140
LVYNVLYYRN
150
GKAFKFFHWN
160
SNLTILKTNI
170
SHNGTYHCSG
180
MGKHRYTSAG
190
ISVTVKELFP
200
APVLNASVTS
210
PLLEGNLVTL
220
SCETKLLLQR
230
PGLQLYFSFY
240
MGSKTLRGRN
250
TSSEYQILTA
260
RREDSGLYWC
270
EAATEDGNVL
280
KRSPELELQV
290
LGLQLPTPVW
300
FHVLFYLAVG
310
IMFLVNTVLW
320
VTIRKELKRK
330
KKWDLEISLD
340
SGHEKKVISS
350
LQEDRHLEEE
360
LKCQEQKEEQ
370
LQEGVHRKEP
QGAT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006955 | immune response |
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0019771 | high-affinity IgG receptor activity |
| Molecular Function | GO:0019864 | IgG binding |
| Molecular Function | GO:0019770 | IgG receptor activity |
| Biological Process | GO:0001788 | antibody-dependent cellular cytotoxicity |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0038094 | Fc-gamma receptor signaling pathway |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.