Search Results
Overview
| Uniprot ID | P12368 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type II-alpha regulatory subunit |
| Gene Name | Prkar2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 187 | TYDILVTKDNQTRSV |
| 277 | IVDVIGEKIYKDGER |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
Protein Sequence
10
MSHIQIPPGL
20
TELLQGYTVE
30
VLRQQPPDLV
40
DFAVEYFTRL
50
REARRQESDS
60
FIAPPTTFHA
70
QESSGVPVIE
80
EDGESESDSD
90
DEDLEVPIPS
100
KFTRRVSVCA
110
ETFNPDEEED
120
NDPRVVHPKT
130
DEQRCRLQEA
140
CKDILLFKNL
150
DQEQLSQVLD
160
AMFEKIVKTD
170
EHVIDQGDDG
180
DNFYVIERGT
190
YDILVTKDNQ
200
TRSVGQYDNR
210
GSFGELALMY
220
NTPRAATIVA
230
TSDGSLWGLD
240
RVTFRRIIVK
250
NNAKKRKMFE
260
SFIESVPLFK
270
SLEMSERMKI
280
VDVIGEKIYK
290
DGERIITQGE
300
KADSFYIIES
310
GEVSILIRSK
320
TKTNKNGGNQ
330
EVEIAHCHKG
340
QYFGELALVT
350
NKPRAASAYA
360
VGDVKCLVMD
370
VQAFERLLGP
380
CMDIMKRNIS
390
HYEEQLVKMF
400
GSNLDLLDPG
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0042585 | germinal vesicle |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031588 | nucleotide-activated protein kinase complex |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0031698 | beta-2 adrenergic receptor binding |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0036094 | small molecule binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:1904146 | positive regulation of meiotic cell cycle process involved in oocyte maturation |
| Biological Process | GO:1903538 | regulation of meiotic cell cycle process involved in oocyte maturation |
| Biological Process | GO:0045859 | regulation of protein kinase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.