Search Results
Overview
| Uniprot ID | P12369 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type II-beta regulatory subunit |
| Gene Name | Prkar2b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 285 | LEVSERLKVVDVIGT |
| 328 | ITMKRKGKSDIEENG |
| 391 | GPCMEIMKRNIATYE |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
Protein Sequence
10
MSIEIPAGLT
20
ELLQGFTVEV
30
LRHQPADLLE
40
FALQHFTRLQ
50
QENERKGAAR
60
FGHEGRTWGD
70
AGAAAGGGTP
80
SKGVNFAEEP
90
MRSDSENGEE
100
EEAAEAGAFN
110
APVINRFTRR
120
ASVCAEAYNP
130
DEEEDDAESR
140
IIHPKTDDQR
150
NRLQEACKDI
160
LLFKNLDPEQ
170
MSQVLDAMFE
180
KLVKEGEHVI
190
DQGDDGDNFY
200
VIDRGTFDIY
210
VKCDGVGRCV
220
GNYDNRGSFG
230
ELALMYNTPR
240
AATITATSPG
250
ALWGLDRVTF
260
RRIIVKNNAK
270
KRKMYESFIE
280
SLPFLKSLEV
290
SERLKVVDVI
300
GTKVYNDGEQ
310
IIAQGDSADS
320
FFIVESGEVR
330
ITMKRKGKSD
340
IEENGAVEIA
350
RCLRGQYFGE
360
LALVTNKPRA
370
ASAHAIGTVK
380
CLAMDVQAFE
390
RLLGPCMEIM
400
KRNIATYEEQ
410
LVALFGTNMD
IVEPTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0045859 | regulation of protein kinase activity |
| Biological Process | GO:0097332 | response to antipsychotic drug |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.