Search Results
Overview
| Uniprot ID | P12382 |
|---|---|
| Protein Name | ATP-dependent 6-phosphofructokinase, liver type |
| Gene Name | Pfkl |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 677 | FDRNYGTKLGVKAML |
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (PubMed:26194095)
Protein Sequence
10
MATVDLEKLR
20
MSGAGKAIGV
30
LTSGGDAQGM
40
NAAVRAVTRM
50
GIYVGAKVFL
60
IYEGYEGLVE
70
GGENIKPANW
80
LSVSNIIQLG
90
GTIIGSARCK
100
AFTTREGRLA
110
AAYNLLQHGI
120
TNLCVIGGDG
130
SLTGANIFRN
140
EWGSLLEELV
150
KEGKISESTA
160
QNYAHLTIAG
170
LVGSIDNDFC
180
GTDMTIGTDS
190
ALHRIMEVID
200
AITTTAQSHQ
210
RTFVLEVMGR
220
HCGYLALVSA
230
LASGADWLFI
240
PEAPPEDGWE
250
NFMCERLGET
260
RSRGSRLNII
270
IIAEGAIDRH
280
GKPISSSYVK
290
DLVVQRLGFD
300
TRVTVLGHVQ
310
RGGTPSAFDR
320
ILSSKMGMEA
330
VMALLEATPD
340
TPACVVSLSG
350
NQSVRLPLME
360
CVQVTKDVQK
370
AMDEERFDEA
380
IQLRGRSFEN
390
NWKIYKLLAH
400
QKVSKEKSNF
410
SLAILNVGAP
420
AAGMNAAVRS
430
AVRTGISEGH
440
TVYIVHDGFE
450
GLAKGQVQEV
460
GWHDVAGWLG
470
RGGSMLGTKR
480
TLPKPHLEAI
490
VENLRTYNIH
500
ALLVIGGFEA
510
YEGVLQLVEA
520
RGRYEELCIV
530
MCVIPATISN
540
NVPGTDFSLG
550
SDTAVNAAME
560
SCDRIKQSAS
570
GTKRRVFIVE
580
TMGGYCGYLA
590
TVTGIAVGAD
600
AAYVFEDPFN
610
IHDLKANVEH
620
MTEKMKTDIQ
630
RGLVLRNEKC
640
HEHYTTEFLY
650
NLYSSEGRGV
660
FDCRTNVLGH
670
LQQGGAPTPF
680
DRNYGTKLGV
690
KAMLWVSEKL
700
RDVYRKGRVF
710
ANAPDSACVI
720
GLRKKVVAFS
730
PVTELKKETD
740
FEHRMPREQW
750
WLNLRLMLKM
760
LAHYRISMAD
770
YVSGELEHVT
780
RRTLSIDKGF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005945 | 6-phosphofructokinase complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0003872 | 6-phosphofructokinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0070061 | fructose binding |
| Molecular Function | GO:0070095 | fructose-6-phosphate binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0048029 | monosaccharide binding |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0030388 | fructose 1,6-bisphosphate metabolic process |
| Biological Process | GO:0006002 | fructose 6-phosphate metabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0061615 | glycolytic process through fructose-6-phosphate |
| Biological Process | GO:0046676 | negative regulation of insulin secretion |
| Biological Process | GO:0009749 | response to glucose |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.