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Overview

Uniprot IDP12429
Protein NameAnnexin A3
Gene NameANXA3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
154 ETSGDFRKALLTLAD
263 ERLHRALKGIGTDEF
58 AQRQLIVKEYQAAYG
66 EYQAAYGKELKDDLK

Function

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

Protein Sequence

10 MASIWVGHRG 20 TVRDYPDFSP 30 SVDAEAIQKA 40 IRGIGTDEKM 50 LISILTERSN 60 AQRQLIVKEY 70 QAAYGKELKD 80 DLKGDLSGHF 90 EHLMVALVTP 100 PAVFDAKQLK 110 KSMKGAGTNE 120 DALIEILTTR 130 TSRQMKDISQ 140 AYYTVYKKSL 150 GDDISSETSG 160 DFRKALLTLA 170 DGRRDESLKV 180 DEHLAKQDAQ 190 ILYKAGENRW 200 GTDEDKFTEI 210 LCLRSFPQLK 220 LTFDEYRNIS 230 QKDIVDSIKG 240 ELSGHFEDLL 250 LAIVNCVRNT 260 PAFLAERLHR 270 ALKGIGTDEF 280 TLNRIMVSRS 290 EIDLLDIRTE 300 FKKHYGYSLY 310 SAIKSDTSGD 320 YEITLLKICG GDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030670 phagocytic vesicle membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042581 specific granule
Cellular Component GO:0012506 vesicle membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0001786 phosphatidylserine binding
Molecular Function GO:0019834 phospholipase A2 inhibitor activity
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0006909 phagocytosis
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0010595 positive regulation of endothelial cell migration

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.