Search Results
Overview
| Uniprot ID | P12532 |
|---|---|
| Protein Name | Creatine kinase U-type, mitochondrial |
| Gene Name | CKMT1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | VDALSGLKGDLAGRY |
| 337 | IKLPLLSKDSRFPKI |
| 343 | SKDSRFPKILENLRL |
| 416 | PTPVIHTKH****** |
| 58 | AEYPDLRKHNNCMAS |
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
Protein Sequence
10
MAGPFSRLLS
20
ARPGLRLLAL
30
AGAGSLAAGF
40
LLRPEPVRAA
50
SERRRLYPPS
60
AEYPDLRKHN
70
NCMASHLTPA
80
VYARLCDKTT
90
PTGWTLDQCI
100
QTGVDNPGHP
110
FIKTVGMVAG
120
DEETYEVFAD
130
LFDPVIQERH
140
NGYDPRTMKH
150
TTDLDASKIR
160
SGYFDERYVL
170
SSRVRTGRSI
180
RGLSLPPACT
190
RAERREVERV
200
VVDALSGLKG
210
DLAGRYYRLS
220
EMTEAEQQQL
230
IDDHFLFDKP
240
VSPLLTAAGM
250
ARDWPDARGI
260
WHNNEKSFLI
270
WVNEEDHTRV
280
ISMEKGGNMK
290
RVFERFCRGL
300
KEVERLIQER
310
GWEFMWNERL
320
GYILTCPSNL
330
GTGLRAGVHI
340
KLPLLSKDSR
350
FPKILENLRL
360
QKRGTGGVDT
370
AATGGVFDIS
380
NLDRLGKSEV
390
ELVQLVIDGV
400
NYLIDCERRL
410
ERGQDIRIPT
PVIHTKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004111 | creatine kinase activity |
| Biological Process | GO:0046314 | phosphocreatine biosynthetic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.