Search Results
Overview
| Uniprot ID | P12724 |
|---|---|
| Protein Name | Eosinophil cationic protein |
| Gene Name | RNASE3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 65 | NNYRWRCKNQNTFLR |
Function
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content
Protein Sequence
10
MVPKLFTSQI
20
CLLLLLGLMG
30
VEGSLHARPP
40
QFTRAQWFAI
50
QHISLNPPRC
60
TIAMRAINNY
70
RWRCKNQNTF
80
LRTTFANVVN
90
VCGNQSIRCP
100
HNRTLNNCHR
110
SRFRVPLLHC
120
DLINPGAQNI
130
SNCTYADRPG
140
RRFYVVACDN
150
RDPRDSPRYP
160
VVPVHLDTTI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0004519 | endonuclease activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0001530 | lipopolysaccharide binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:0004540 | RNA nuclease activity |
| Biological Process | GO:0019731 | antibacterial humoral response |
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0050829 | defense response to Gram-negative bacterium |
| Biological Process | GO:0050830 | defense response to Gram-positive bacterium |
| Biological Process | GO:0043152 | induction of bacterial agglutination |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0002227 | innate immune response in mucosa |
| Biological Process | GO:0006401 | RNA catabolic process |
Reference
PMID: N/A