Search Results
Overview
| Uniprot ID | P12757 |
|---|---|
| Protein Name | Ski-like protein |
| Gene Name | SKIL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 352 | KIILEEMKEKFSMRS |
| 354 | ILEEMKEKFSMRSGK |
| 45 | ANGKTINKVPTVKKE |
| 487 | ISNNSTSKRKSESAT |
Function
May have regulatory role in cell division or differentiation in response to extracellular signals
Protein Sequence
10
MENLQTNFSL
20
VQGSTKKLNG
30
MGDDGSPPAK
40
KMITDIHANG
50
KTINKVPTVK
60
KEHLDDYGEA
70
PVETDGEHVK
80
RTCTSVPETL
90
HLNPSLKHTL
100
AQFHLSSQSS
110
LGGPAAFSAR
120
HSQESMSPTV
130
FLPLPSPQVL
140
PGPLLIPSDS
150
STELTQTVLE
160
GESISCFQVG
170
GEKRLCLPQV
180
LNSVLREFTL
190
QQINTVCDEL
200
YIYCSRCTSD
210
QLHILKVLGI
220
LPFNAPSCGL
230
ITLTDAQRLC
240
NALLRPRTFP
250
QNGSVLPAKS
260
SLAQLKETGS
270
AFEVEHECLG
280
KCQGLFAPQF
290
YVQPDAPCIQ
300
CLECCGMFAP
310
QTFVMHSHRS
320
PDKRTCHWGF
330
ESAKWHCYLH
340
VNQKYLGTPE
350
EKKLKIILEE
360
MKEKFSMRSG
370
KRNQSKTDAP
380
SGMELQSWYP
390
VIKQEGDHVS
400
QTHSFLHPSY
410
YLYMCDKVVA
420
PNVSLTSAVS
430
QSKELTKTEA
440
SKSISRQSEK
450
AHSSGKLQKT
460
VSYPDVSLEE
470
QEKMDLKTSR
480
ELCSRLDASI
490
SNNSTSKRKS
500
ESATCNLVRD
510
INKVGIGLVA
520
AASSPLLVKD
530
VICEDDKGKI
540
MEEVMRTYLK
550
QQEKLNLILQ
560
KKQQLQMEVK
570
MLSSSKSMKE
580
LTEEQQNLQK
590
ELESLQNEHA
600
QRMEEFYVEQ
610
KDLEKKLEQI
620
MKQKCTCDSN
630
LEKDKEAEYA
640
GQLAELRQRL
650
DHAEADRQEL
660
QDELRQEREA
670
RQKLEMMIKE
680
LKLQILKSSK
TAKE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0046332 | SMAD binding |
| Biological Process | GO:0061061 | muscle structure development |
| Biological Process | GO:0030514 | negative regulation of BMP signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0050772 | positive regulation of axonogenesis |
| Biological Process | GO:0046677 | response to antibiotic |
| Biological Process | GO:0034097 | response to cytokine |
| Biological Process | GO:0070848 | response to growth factor |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.