Search Results

Overview

Uniprot IDP12814
Protein NameAlpha-actinin-1
Gene NameACTN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 ALDFIASKGVKLVSI
195 PELIDYGKLRKDDPL
198 IDYGKLRKDDPLTNL
35 AWEKQQRKTFTAWCN
413 HEAWTDGKEAMLRQK
420 KEAMLRQKDYETATL
436 EIKALLKKHEAFESD
47 WCNSHLRKAGTQIEN
492 NLGALTQKRREALER
563 ATLPDADKERLAILG
676 SHLRQYEKSIVNYKP
704 EALIFDNKHTNYTME
840 FKILAGDKNYITMDE
89 RGKMRVHKISNVNKA
95 HKISNVNKALDFIAS

Function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882)

Protein Sequence

10 MDHYDSQQTN 20 DYMQPEEDWD 30 RDLLLDPAWE 40 KQQRKTFTAW 50 CNSHLRKAGT 60 QIENIEEDFR 70 DGLKLMLLLE 80 VISGERLAKP 90 ERGKMRVHKI 100 SNVNKALDFI 110 ASKGVKLVSI 120 GAEEIVDGNV 130 KMTLGMIWTI 140 ILRFAIQDIS 150 VEETSAKEGL 160 LLWCQRKTAP 170 YKNVNIQNFH 180 ISWKDGLGFC 190 ALIHRHRPEL 200 IDYGKLRKDD 210 PLTNLNTAFD 220 VAEKYLDIPK 230 MLDAEDIVGT 240 ARPDEKAIMT 250 YVSSFYHAFS 260 GAQKAETAAN 270 RICKVLAVNQ 280 ENEQLMEDYE 290 KLASDLLEWI 300 RRTIPWLENR 310 VPENTMHAMQ 320 QKLEDFRDYR 330 RLHKPPKVQE 340 KCQLEINFNT 350 LQTKLRLSNR 360 PAFMPSEGRM 370 VSDINNAWGC 380 LEQVEKGYEE 390 WLLNEIRRLE 400 RLDHLAEKFR 410 QKASIHEAWT 420 DGKEAMLRQK 430 DYETATLSEI 440 KALLKKHEAF 450 ESDLAAHQDR 460 VEQIAAIAQE 470 LNELDYYDSP 480 SVNARCQKIC 490 DQWDNLGALT 500 QKRREALERT 510 EKLLETIDQL 520 YLEYAKRAAP 530 FNNWMEGAME 540 DLQDTFIVHT 550 IEEIQGLTTA 560 HEQFKATLPD 570 ADKERLAILG 580 IHNEVSKIVQ 590 TYHVNMAGTN 600 PYTTITPQEI 610 NGKWDHVRQL 620 VPRRDQALTE 630 EHARQQHNER 640 LRKQFGAQAN 650 VIGPWIQTKM 660 EEIGRISIEM 670 HGTLEDQLSH 680 LRQYEKSIVN 690 YKPKIDQLEG 700 DHQLIQEALI 710 FDNKHTNYTM 720 EHIRVGWEQL 730 LTTIARTINE 740 VENQILTRDA 750 KGISQEQMNE 760 FRASFNHFDR 770 DHSGTLGPEE 780 FKACLISLGY 790 DIGNDPQGEA 800 EFARIMSIVD 810 PNRLGVVTFQ 820 AFIDFMSRET 830 ADTDTADQVM 840 ASFKILAGDK 850 NYITMDELRR 860 ELPPDQAEYC 870 IARMAPYTGP 880 DSVPGALDYM 890 SFSTALYGES DL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005903 brush border
Cellular Component GO:0030054 cell junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005916 fascia adherens
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031093 platelet alpha granule lumen
Cellular Component GO:0031143 pseudopodium
Cellular Component GO:0001726 ruffle
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0099186 structural constituent of postsynapse
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0044325 transmembrane transporter binding
Molecular Function GO:0017166 vinculin binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0051639 actin filament network formation
Biological Process GO:0007015 actin filament organization
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0055001 muscle cell development
Biological Process GO:0030220 platelet formation
Biological Process GO:0036344 platelet morphogenesis
Biological Process GO:0042981 regulation of apoptotic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.