Search Results
Overview
| Uniprot ID | P12839 |
|---|---|
| Protein Name | Neurofilament medium polypeptide |
| Gene Name | Nefm |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | KLSRSNEKEQLQGLN |
| 126 | HYLEQQNKEIEAEIH |
| 167 | LEMVNHEKAQVQLDS |
| 207 | AAIRAVRKDIEESSM |
| 222 | VKVELDKKVQSLQDE |
| 262 | VERKDYLKTDISTAL |
| 270 | TDISTALKEIRSQLE |
| 297 | WFKCRYAKLTEAAEQ |
| 306 | TEAAEQNKEAIRSAK |
| 313 | KEAIRSAKEEIAEYR |
| 326 | YRRQLQSKSIELESV |
| 373 | ENELRGTKWEMARHL |
| 402 | IEIAAYRKLLEGEET |
| 435 | PSVTISSKIQKTKVE |
| 445 | KTKVEAPKLKVQHKF |
| 451 | PKLKVQHKFVEEIIE |
| 54 | STVSSSYKRSALAPR |
| 584 | EEKKTEGKVEEMAIK |
| 595 | MAIKEEIKVEKPEKA |
| 601 | IKVEKPEKAKSPVPK |
| 617 | PVEEVKPKPEAKAGK |
| 624 | KPEAKAGKDEQKEEE |
| 657 | EKKEEKPKDVPDKKK |
| 672 | AESPVKEKAVEEMIT |
| 685 | ITITKSVKVSLEKDT |
| 690 | SVKVSLEKDTKEEKP |
| 693 | VSLEKDTKEEKPQQQ |
| 702 | EKPQQQEKVKEKAEE |
| 781 | GEDRSDDKVVVTKKV |
| 787 | DKVVVTKKVEKITSE |
| 790 | VVTKKVEKITSEGGD |
| 801 | EGGDGATKYITKSVT |
| 805 | GATKYITKSVTVTQK |
| 812 | KSVTVTQKVEEHEET |
| 823 | HEETFEEKLVSTKKV |
| 832 | VSTKKVEKVTSHAIV |
| 840 | VTSHAIVKEVTQGD* |
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)
Protein Sequence
10
MSYTLDSLGN
20
PSAYRRVPTE
30
TRSSFSRVSG
40
SPSSGFRSQS
50
WSRGSPSTVS
60
SSYKRSALAP
70
RLAYSSAMLS
80
SAESSLDFSQ
90
SSSLLNGGSG
100
GDYKLSRSNE
110
KEQLQGLNDR
120
FAGYIEKVHY
130
LEQQNKEIEA
140
EIHALRQKQA
150
SHAQLGDAYD
160
QEIRELRATL
170
EMVNHEKAQV
180
QLDSDHLEED
190
IHRLKERFEE
200
EARLRDDTEA
210
AIRAVRKDIE
220
ESSMVKVELD
230
KKVQSLQDEV
240
AFLRSNHEEE
250
VADLLAQIQA
260
SHITVERKDY
270
LKTDISTALK
280
EIRSQLECHS
290
DQNMHQAEEW
300
FKCRYAKLTE
310
AAEQNKEAIR
320
SAKEEIAEYR
330
RQLQSKSIEL
340
ESVRGTKESL
350
ERQLSDIEER
360
HNHDLSSYQD
370
TIQQLENELR
380
GTKWEMARHL
390
REYQDLLNVK
400
MALDIEIAAY
410
RKLLEGEETR
420
FSTFSGSITG
430
PLYTHRQPSV
440
TISSKIQKTK
450
VEAPKLKVQH
460
KFVEEIIEET
470
KVEDEKSEME
480
DALTVIAEEL
490
AASAKEEKEE
500
AEEKEEEPEV
510
EKSPVKSPEA
520
KEEEEGEKEE
530
EEEGQEEEEE
540
EDEGVKSDQA
550
EEGGSEKEGS
560
SEKDEGEQEE
570
EGETEAEGEG
580
EEAEAKEEKK
590
TEGKVEEMAI
600
KEEIKVEKPE
610
KAKSPVPKSP
620
VEEVKPKPEA
630
KAGKDEQKEE
640
EKVEEKKEVA
650
KESPKEEKVE
660
KKEEKPKDVP
670
DKKKAESPVK
680
EKAVEEMITI
690
TKSVKVSLEK
700
DTKEEKPQQQ
710
EKVKEKAEEE
720
GGSEEEVGDK
730
SPQESKKEDI
740
AINGEVEGKE
750
EEEQETQEKG
760
SGQEEEKGVV
770
TNGLDVSPAE
780
EKKGEDRSDD
790
KVVVTKKVEK
800
ITSEGGDGAT
810
KYITKSVTVT
820
QKVEEHEETF
830
EEKLVSTKKV
840
EKVTSHAIVK
EVTQGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045111 | intermediate filament cytoskeleton |
| Cellular Component | GO:0097418 | neurofibrillary tangle |
| Cellular Component | GO:0005883 | neurofilament |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
| Cellular Component | GO:0099182 | presynaptic intermediate filament cytoskeleton |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0015643 | toxic substance binding |
| Biological Process | GO:0008088 | axo-dendritic transport |
| Biological Process | GO:0031103 | axon regeneration |
| Biological Process | GO:0071392 | cellular response to estradiol stimulus |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0045110 | intermediate filament bundle assembly |
| Biological Process | GO:0045104 | intermediate filament cytoskeleton organization |
| Biological Process | GO:0045105 | intermediate filament polymerization or depolymerization |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0033693 | neurofilament bundle assembly |
| Biological Process | GO:0060052 | neurofilament cytoskeleton organization |
| Biological Process | GO:0031133 | regulation of axon diameter |
| Biological Process | GO:1903937 | response to acrylamide |
| Biological Process | GO:0021510 | spinal cord development |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.