Search Results

Overview

Uniprot IDP12882
Protein NameMyosin-1
Gene NameMYH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1199 TAATLRKKHADSVAE
1378 EVAQWRTKYETDAIQ
1414 HVEAVNAKCASLEKT
1655 RNTQAILKDTQLHLD
1731 NTSLINTKKKLETDI
30 ERIEAQNKPFDAKTS
35 QNKPFDAKTSVFVVD
408 ALCYPRVKVGNEYVT
44 SVFVVDPKESFVKAT
568 GKSNNFQKPKPAKGK
601 AGWLDKNKDPLNETV
63 EGGKVTAKTEAGATV
638 EAEAGGGKKGGKKKG
84 VFPMNPPKYDKIEDM
869 KTKEELAKTEAKRKE
922 TKIQLEAKIKEVTER
946 ELTAKKRKLEDECSE
955 EDECSELKKDIDDLE

Function

Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility

Protein Sequence

10 MSSDSEMAIF 20 GEAAPFLRKS 30 ERERIEAQNK 40 PFDAKTSVFV 50 VDPKESFVKA 60 TVQSREGGKV 70 TAKTEAGATV 80 TVKDDQVFPM 90 NPPKYDKIED 100 MAMMTHLHEP 110 AVLYNLKERY 120 AAWMIYTYSG 130 LFCVTVNPYK 140 WLPVYNAEVV 150 TAYRGKKRQE 160 APPHIFSISD 170 NAYQFMLTDR 180 ENQSILITGE 190 SGAGKTVNTK 200 RVIQYFATIA 210 VTGEKKKEEV 220 TSGKMQGTLE 230 DQIISANPLL 240 EAFGNAKTVR 250 NDNSSRFGKF 260 IRIHFGTTGK 270 LASADIETYL 280 LEKSRVTFQL 290 KAERSYHIFY 300 QIMSNKKPDL 310 IEMLLITTNP 320 YDYAFVSQGE 330 ITVPSIDDQE 340 ELMATDSAIE 350 ILGFTSDERV 360 SIYKLTGAVM 370 HYGNMKFKQK 380 QREEQAEPDG 390 TEVADKAAYL 400 QNLNSADLLK 410 ALCYPRVKVG 420 NEYVTKGQTV 430 QQVYNAVGAL 440 AKAVYDKMFL 450 WMVTRINQQL 460 DTKQPRQYFI 470 GVLDIAGFEI 480 FDFNSLEQLC 490 INFTNEKLQQ 500 FFNHHMFVLE 510 QEEYKKEGIE 520 WTFIDFGMDL 530 AACIELIEKP 540 MGIFSILEEE 550 CMFPKATDTS 560 FKNKLYEQHL 570 GKSNNFQKPK 580 PAKGKPEAHF 590 SLIHYAGTVD 600 YNIAGWLDKN 610 KDPLNETVVG 620 LYQKSAMKTL 630 ALLFVGATGA 640 EAEAGGGKKG 650 GKKKGSSFQT 660 VSALFRENLN 670 KLMTNLRSTH 680 PHFVRCIIPN 690 ETKTPGAMEH 700 ELVLHQLRCN 710 GVLEGIRICR 720 KGFPSRILYA 730 DFKQRYKVLN 740 ASAIPEGQFI 750 DSKKASEKLL 760 GSIDIDHTQY 770 KFGHTKVFFK 780 AGLLGLLEEM 790 RDEKLAQLIT 800 RTQAMCRGFL 810 ARVEYQKMVE 820 RRESIFCIQY 830 NVRAFMNVKH 840 WPWMKLYFKI 850 KPLLKSAETE 860 KEMANMKEEF 870 EKTKEELAKT 880 EAKRKELEEK 890 MVTLMQEKND 900 LQLQVQAEAD 910 SLADAEERCD 920 QLIKTKIQLE 930 AKIKEVTERA 940 EDEEEINAEL 950 TAKKRKLEDE 960 CSELKKDIDD 970 LELTLAKVEK 980 EKHATENKVK 990 NLTEEMAGLD 1000 ETIAKLTKEK 1010 KALQEAHQQT 1020 LDDLQAEEDK 1030 VNTLTKAKIK 1040 LEQQVDDLEG 1050 SLEQEKKIRM 1060 DLERAKRKLE 1070 GDLKLAQEST 1080 MDIENDKQQL 1090 DEKLKKKEFE 1100 MSGLQSKIED 1110 EQALGMQLQK 1120 KIKELQARIE 1130 ELEEEIEAER 1140 ASRAKAEKQR 1150 SDLSRELEEI 1160 SERLEEAGGA 1170 TSAQIEMNKK 1180 REAEFQKMRR 1190 DLEEATLQHE 1200 ATAATLRKKH 1210 ADSVAELGEQ 1220 IDNLQRVKQK 1230 LEKEKSEMKM 1240 EIDDLASNME 1250 TVSKAKGNLE 1260 KMCRALEDQL 1270 SEIKTKEEEQ 1280 QRLINDLTAQ 1290 RARLQTESGE 1300 YSRQLDEKDT 1310 LVSQLSRGKQ 1320 AFTQQIEELK 1330 RQLEEEIKAK 1340 SALAHALQSS 1350 RHDCDLLREQ 1360 YEEEQEAKAE 1370 LQRAMSKANS 1380 EVAQWRTKYE 1390 TDAIQRTEEL 1400 EEAKKKLAQR 1410 LQDAEEHVEA 1420 VNAKCASLEK 1430 TKQRLQNEVE 1440 DLMIDVERTN 1450 AACAALDKKQ 1460 RNFDKILAEW 1470 KQKCEETHAE 1480 LEASQKESRS 1490 LSTELFKIKN 1500 AYEESLDQLE 1510 TLKRENKNLQ 1520 QEISDLTEQI 1530 AEGGKRIHEL 1540 EKIKKQVEQE 1550 KSELQAALEE 1560 AEASLEHEEG 1570 KILRIQLELN 1580 QVKSEVDRKI 1590 AEKDEEIDQM 1600 KRNHIRIVES 1610 MQSTLDAEIR 1620 SRNDAIRLKK 1630 KMEGDLNEME 1640 IQLNHANRMA 1650 AEALRNYRNT 1660 QAILKDTQLH 1670 LDDALRSQED 1680 LKEQLAMVER 1690 RANLLQAEIE 1700 ELRATLEQTE 1710 RSRKIAEQEL 1720 LDASERVQLL 1730 HTQNTSLINT 1740 KKKLETDISQ 1750 IQGEMEDIIQ 1760 EARNAEEKAK 1770 KAITDAAMMA 1780 EELKKEQDTS 1790 AHLERMKKNL 1800 EQTVKDLQHR 1810 LDEAEQLALK 1820 GGKKQIQKLE 1830 ARVRELEGEV 1840 ESEQKRNVEA 1850 VKGLRKHERK 1860 VKELTYQTEE 1870 DRKNILRLQD 1880 LVDKLQAKVK 1890 SYKRQAEEAE 1900 EQSNVNLSKF 1910 RRIQHELEEA 1920 EERADIAESQ 1930 VNKLRVKSRE VHTKIISEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031672 A band
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Biological Process GO:0006936 muscle contraction
Biological Process GO:0007605 sensory perception of sound
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0005859 muscle myosin complex

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.