Search Results

Overview

Uniprot IDP12883
Protein NameMyosin-7
Gene NameMYH7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1305 ISQLTRGKLTYTQQL
1316 TQQLEDLKRQLEEEV
951 EDECSELKRDIDDLE

Function

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle

Protein Sequence

10 MGDSEMAVFG 20 AAAPYLRKSE 30 KERLEAQTRP 40 FDLKKDVFVP 50 DDKQEFVKAK 60 IVSREGGKVT 70 AETEYGKTVT 80 VKEDQVMQQN 90 PPKFDKIEDM 100 AMLTFLHEPA 110 VLYNLKDRYG 120 SWMIYTYSGL 130 FCVTVNPYKW 140 LPVYTPEVVA 150 AYRGKKRSEA 160 PPHIFSISDN 170 AYQYMLTDRE 180 NQSILITGES 190 GAGKTVNTKR 200 VIQYFAVIAA 210 IGDRSKKDQS 220 PGKGTLEDQI 230 IQANPALEAF 240 GNAKTVRNDN 250 SSRFGKFIRI 260 HFGATGKLAS 270 ADIETYLLEK 280 SRVIFQLKAE 290 RDYHIFYQIL 300 SNKKPELLDM 310 LLITNNPYDY 320 AFISQGETTV 330 ASIDDAEELM 340 ATDNAFDVLG 350 FTSEEKNSMY 360 KLTGAIMHFG 370 NMKFKLKQRE 380 EQAEPDGTEE 390 ADKSAYLMGL 400 NSADLLKGLC 410 HPRVKVGNEY 420 VTKGQNVQQV 430 IYATGALAKA 440 VYERMFNWMV 450 TRINATLETK 460 QPRQYFIGVL 470 DIAGFEIFDF 480 NSFEQLCINF 490 TNEKLQQFFN 500 HHMFVLEQEE 510 YKKEGIEWTF 520 IDFGMDLQAC 530 IDLIEKPMGI 540 MSILEEECMF 550 PKATDMTFKA 560 KLFDNHLGKS 570 ANFQKPRNIK 580 GKPEAHFSLI 590 HYAGIVDYNI 600 IGWLQKNKDP 610 LNETVVGLYQ 620 KSSLKLLSTL 630 FANYAGADAP 640 IEKGKGKAKK 650 GSSFQTVSAL 660 HRENLNKLMT 670 NLRSTHPHFV 680 RCIIPNETKS 690 PGVMDNPLVM 700 HQLRCNGVLE 710 GIRICRKGFP 720 NRILYGDFRQ 730 RYRILNPAAI 740 PEGQFIDSRK 750 GAEKLLSSLD 760 IDHNQYKFGH 770 TKVFFKAGLL 780 GLLEEMRDER 790 LSRIITRIQA 800 QSRGVLARME 810 YKKLLERRDS 820 LLVIQWNIRA 830 FMGVKNWPWM 840 KLYFKIKPLL 850 KSAEREKEMA 860 SMKEEFTRLK 870 EALEKSEARR 880 KELEEKMVSL 890 LQEKNDLQLQ 900 VQAEQDNLAD 910 AEERCDQLIK 920 NKIQLEAKVK 930 EMNERLEDEE 940 EMNAELTAKK 950 RKLEDECSEL 960 KRDIDDLELT 970 LAKVEKEKHA 980 TENKVKNLTE 990 EMAGLDEIIA 1000 KLTKEKKALQ 1010 EAHQQALDDL 1020 QAEEDKVNTL 1030 TKAKVKLEQQ 1040 VDDLEGSLEQ 1050 EKKVRMDLER 1060 AKRKLEGDLK 1070 LTQESIMDLE 1080 NDKQQLDERL 1090 KKKDFELNAL 1100 NARIEDEQAL 1110 GSQLQKKLKE 1120 LQARIEELEE 1130 ELEAERTARA 1140 KVEKLRSDLS 1150 RELEEISERL 1160 EEAGGATSVQ 1170 IEMNKKREAE 1180 FQKMRRDLEE 1190 ATLQHEATAA 1200 ALRKKHADSV 1210 AELGEQIDNL 1220 QRVKQKLEKE 1230 KSEFKLELDD 1240 VTSNMEQIIK 1250 AKANLEKMCR 1260 TLEDQMNEHR 1270 SKAEETQRSV 1280 NDLTSQRAKL 1290 QTENGELSRQ 1300 LDEKEALISQ 1310 LTRGKLTYTQ 1320 QLEDLKRQLE 1330 EEVKAKNALA 1340 HALQSARHDC 1350 DLLREQYEEE 1360 TEAKAELQRV 1370 LSKANSEVAQ 1380 WRTKYETDAI 1390 QRTEELEEAK 1400 KKLAQRLQEA 1410 EEAVEAVNAK 1420 CSSLEKTKHR 1430 LQNEIEDLMV 1440 DVERSNAAAA 1450 ALDKKQRNFD 1460 KILAEWKQKY 1470 EESQSELESS 1480 QKEARSLSTE 1490 LFKLKNAYEE 1500 SLEHLETFKR 1510 ENKNLQEEIS 1520 DLTEQLGSSG 1530 KTIHELEKVR 1540 KQLEAEKMEL 1550 QSALEEAEAS 1560 LEHEEGKILR 1570 AQLEFNQIKA 1580 EIERKLAEKD 1590 EEMEQAKRNH 1600 LRVVDSLQTS 1610 LDAETRSRNE 1620 ALRVKKKMEG 1630 DLNEMEIQLS 1640 HANRMAAEAQ 1650 KQVKSLQSLL 1660 KDTQIQLDDA 1670 VRANDDLKEN 1680 IAIVERRNNL 1690 LQAELEELRA 1700 VVEQTERSRK 1710 LAEQELIETS 1720 ERVQLLHSQN 1730 TSLINQKKKM 1740 DADLSQLQTE 1750 VEEAVQECRN 1760 AEEKAKKAIT 1770 DAAMMAEELK 1780 KEQDTSAHLE 1790 RMKKNMEQTI 1800 KDLQHRLDEA 1810 EQIALKGGKK 1820 QLQKLEARVR 1830 ELENELEAEQ 1840 KRNAESVKGM 1850 RKSERRIKEL 1860 TYQTEEDRKN 1870 LLRLQDLVDK 1880 LQLKVKAYKR 1890 QAEEAEEQAN 1900 TNLSKFRKVQ 1910 HELDEAEERA 1920 DIAESQVNKL 1930 RAKSRDIGTK GLNEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005859 muscle myosin complex
Cellular Component GO:0030016 myofibril
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Biological Process GO:0007512 adult heart development
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0014728 regulation of the force of skeletal muscle contraction
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.