Search Results
Overview
| Uniprot ID | P12955 |
|---|---|
| Protein Name | Xaa-Pro dipeptidase |
| Gene Name | PEPD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | SHATWMGKIHSKEHF |
| 200 | EVLRYTNKISSEAHR |
Function
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654)
Protein Sequence
10
MAAATGPSFW
20
LGNETLKVPL
30
ALFALNRQRL
40
CERLRKNPAV
50
QAGSIVVLQG
60
GEETQRYCTD
70
TGVLFRQESF
80
FHWAFGVTEP
90
GCYGVIDVDT
100
GKSTLFVPRL
110
PASHATWMGK
120
IHSKEHFKEK
130
YAVDDVQYVD
140
EIASVLTSQK
150
PSVLLTLRGV
160
NTDSGSVCRE
170
ASFDGISKFE
180
VNNTILHPEI
190
VECRVFKTDM
200
ELEVLRYTNK
210
ISSEAHREVM
220
KAVKVGMKEY
230
ELESLFEHYC
240
YSRGGMRHSS
250
YTCICGSGEN
260
SAVLHYGHAG
270
APNDRTIQNG
280
DMCLFDMGGE
290
YYCFASDITC
300
SFPANGKFTA
310
DQKAVYEAVL
320
RSSRAVMGAM
330
KPGVWWPDMH
340
RLADRIHLEE
350
LAHMGILSGS
360
VDAMVQAHLG
370
AVFMPHGLGH
380
FLGIDVHDVG
390
GYPEGVERID
400
EPGLRSLRTA
410
RHLQPGMVLT
420
VEPGIYFIDH
430
LLDEALADPA
440
RASFLNREVL
450
QRFRGFGGVR
460
IEEDVVVTDS
470
GIELLTCVPR
480
TVEEIEACMA
490
GCDKAFTPFS
GPK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0004181 | metallocarboxypeptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Molecular Function | GO:0102009 | proline dipeptidase activity |
| Biological Process | GO:0006520 | amino acid metabolic process |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0043069 | negative regulation of programmed cell death |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.