Overview
| Uniprot ID | P13056 |
|---|
| Protein Name | Nuclear receptor subfamily 2 group C member 1 |
|---|
| Gene Name | NR2C1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 143 |
FFKRSIRKNLVYSCR |
| 153 |
VYSCRGSKDCIINKH |
Function
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation
Protein Sequence
10
MATIEEIAHQ
20
IIEQQMGEIV
30
TEQQTGQKIQ
40
IVTALDHNTQ
50
GKQFILTNHD
60
GSTPSKVILA
70
RQDSTPGKVF
80
LTTPDAAGVN
90
QLFFTTPDLS
100
AQHLQLLTDN
110
SPDQGPNKVF
120
DLCVVCGDKA
130
SGRHYGAVTC
140
EGCKGFFKRS
150
IRKNLVYSCR
160
GSKDCIINKH
170
HRNRCQYCRL
180
QRCIAFGMKQ
190
DSVQCERKPI
200
EVSREKSSNC
210
AASTEKIYIR
220
KDLRSPLTAT
230
PTFVTDSEST
240
RSTGLLDSGM
250
FMNIHPSGVK
260
TESAVLMTSD
270
KAESCQGDLS
280
TLANVVTSLA
290
NLGKTKDLSQ
300
NSNEMSMIES
310
LSNDDTSLCE
320
FQEMQTNGDV
330
SRAFDTLAKA
340
LNPGESTACQ
350
SSVAGMEGSV
360
HLITGDSSIN
370
YTEKEGPLLS
380
DSHVAFRLTM
390
PSPMPEYLNV
400
HYIGESASRL
410
LFLSMHWALS
420
IPSFQALGQE
430
NSISLVKAYW
440
NELFTLGLAQ
450
CWQVMNVATI
460
LATFVNCLHN
470
SLQQDKMSTE
480
RRKLLMEHIF
490
KLQEFCNSMV
500
KLCIDGYEYA
510
YLKAIVLFSP
520
DHPSLENMEQ
530
IEKFQEKAYV
540
EFQDYITKTY
550
PDDTYRLSRL
560
LLRLPALRLM
570
NATITEELFF
580
KGLIGNIRID
590
SVIPHILKME
600
PADYNSQIIG
HSI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0042826 |
histone deacetylase binding |
| Molecular Function |
GO:0004879 |
nuclear receptor activity |
| Molecular Function |
GO:0003707 |
nuclear steroid receptor activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0048386 |
positive regulation of retinoic acid receptor signaling pathway |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.