Search Results
Overview
| Uniprot ID | P13084 |
|---|---|
| Protein Name | Nucleophosmin |
| Gene Name | Npm1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | KLLGMSGKRSAPGGG |
| 150 | SAPGGGNKVPQKKVK |
| 201 | SVRDTPAKNAQKSNQ |
| 221 | KPSTPRSKGQESFKK |
| 227 | SKGQESFKKQEKTPK |
| 237 | EKTPKTPKGPSSVED |
| 246 | PSSVEDIKAKMQASI |
| 248 | SVEDIKAKMQASIEK |
| 255 | KMQASIEKGGSLPKV |
| 265 | SLPKVEAKFINYVKN |
| 27 | GCELKADKDYHFKVD |
| 271 | AKFINYVKNCFRMTD |
Function
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes (By similarity). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010826 | negative regulation of centrosome duplication |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| Biological Process | GO:0006913 | nucleocytoplasmic transport |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0009891 | positive regulation of biosynthetic process |
| Biological Process | GO:0043085 | positive regulation of catalytic activity |
| Biological Process | GO:1902751 | positive regulation of cell cycle G2/M phase transition |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010825 | positive regulation of centrosome duplication |
| Biological Process | GO:0051054 | positive regulation of DNA metabolic process |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045860 | positive regulation of protein kinase activity |
| Biological Process | GO:1904751 | positive regulation of protein localization to nucleolus |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0010608 | post-transcriptional regulation of gene expression |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:0046599 | regulation of centriole replication |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
| Biological Process | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA |
| Biological Process | GO:1902629 | regulation of mRNA stability involved in cellular response to UV |
| Biological Process | GO:0043523 | regulation of neuron apoptotic process |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
| Biological Process | GO:0000055 | ribosomal large subunit export from nucleus |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0000056 | ribosomal small subunit export from nucleus |
| Biological Process | GO:0009303 | rRNA transcription |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001652 | granular component |
| Cellular Component | GO:0015934 | large ribosomal subunit |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0015935 | small ribosomal subunit |
| Cellular Component | GO:0031616 | spindle pole centrosome |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001046 | core promoter sequence-specific DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043422 | protein kinase B binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Molecular Function | GO:0043023 | ribosomal large subunit binding |
| Molecular Function | GO:0043024 | ribosomal small subunit binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0030957 | Tat protein binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0003300 | cardiac muscle hypertrophy |
| Biological Process | GO:0006884 | cell volume homeostasis |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0071394 | cellular response to testosterone stimulus |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0007098 | centrosome cycle |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0030225 | macrophage differentiation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.