Search Results
Overview
| Uniprot ID | P13086 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
| Gene Name | Suclg1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | LPVFNTVKEAKEKTG |
| 308 | GAIIAGGKGGAKEKI |
| 48 | GSYTASRKNIYIDKN |
| 54 | RKNIYIDKNTKVICQ |
| 57 | IYIDKNTKVICQGFT |
| 66 | ICQGFTGKQGTFHSQ |
| 90 | VGGTTPGKGGKKHLG |
| 94 | TPGKGGKKHLGLPVF |
Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MTAAVVAAAA
20
TATMVSGSSG
30
LAAARLLSRT
40
FLLQQNGIRH
50
GSYTASRKNI
60
YIDKNTKVIC
70
QGFTGKQGTF
80
HSQQALEYGT
90
KLVGGTTPGK
100
GGKKHLGLPV
110
FNTVKEAKEK
120
TGATASVIYV
130
PPPFAAAAIN
140
EAIDAEIPLV
150
VCITEGIPQQ
160
DMVRVKHKLT
170
RQGKTRLIGP
180
NCPGIINPGE
190
CKIGIMPGHI
200
HKKGRIGIVS
210
RSGTLTYEAV
220
HQTTQVGLGQ
230
SLCIGIGGDP
240
FNGTNFIDCL
250
DVFLKDPATE
260
GIVLIGEIGG
270
HAEENAAEFL
280
KEHNSGPKAK
290
PVVSFIAGIT
300
APPGRRMGHA
310
GAIIAGGKGG
320
AKEKISALQS
330
AGVIVSMSPA
340
QLGTCMYKEF
EKRKML
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1902494 | catalytic complex |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0009361 | succinate-CoA ligase complex (ADP-forming) |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0050074 | malate-CoA ligase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Molecular Function | GO:0004774 | succinate-CoA ligase activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0006105 | succinate metabolic process |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0110052 | toxic metabolite repair |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.