Search Results
Overview
| Uniprot ID | P13107 |
|---|---|
| Protein Name | Cytochrome P450 2B3 |
| Gene Name | Cyp2b3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | MRDFGIGKQSVEDQI |
Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
Protein Sequence
10
MDTSVLLLLA
20
VLLSFLLFLV
30
RGHAKVHGHL
40
PPGPRPLPLL
50
GNLLQMDRGG
60
FRKSFIQLQE
70
KHGDVFTVYF
80
GPRPVVMLCG
90
TQTIREALVD
100
HAEAFSGRGI
110
IAVLQPIMQE
120
YGVSFVNEER
130
WKILRRLFVA
140
TMRDFGIGKQ
150
SVEDQIKEEA
160
KCLVEELKNH
170
QGVSLDPTFL
180
FQCVTGNIIC
190
SIVFGERFDY
200
RDRQFLRLLD
210
LLYRTFSLIS
220
SFSSQMFEVY
230
SDFLKYFPGV
240
HREIYKNLKE
250
VLDYIDHSVE
260
NHRATLDPNA
270
PRDFIDTFLL
280
HMEKEKLNHY
290
TEFHHWNLMI
300
SVLFLFLAGT
310
ESTSNTLCYG
320
FLLMLKYPHV
330
AEKVQKEIDQ
340
VIGSQRVPTL
350
DDRSKMPYTE
360
AVIHEIQRFS
370
DVSPMGLPCR
380
ITKDTLFRGY
390
LLPKNTEVYF
400
ILSSALHDPQ
410
YFEQPDTFNP
420
EHFLDANGAL
430
KKCEAFMPFS
440
IGKRMCLGEG
450
IARSELFLFF
460
TTILQNYSVS
470
SPVDPNTIDM
480
TPKESGLAKV
490
APVYKICFVA
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0062188 | anandamide 11,12 epoxidase activity |
| Molecular Function | GO:0062189 | anandamide 14,15 epoxidase activity |
| Molecular Function | GO:0062187 | anandamide 8,9 epoxidase activity |
| Molecular Function | GO:0008392 | arachidonate epoxygenase activity |
| Molecular Function | GO:0101021 | estrogen 2-hydroxylase activity |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0004497 | monooxygenase activity |
| Molecular Function | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Molecular Function | GO:0008390 | testosterone 16-alpha-hydroxylase activity |
| Molecular Function | GO:0062184 | testosterone 16-beta-hydroxylase activity |
| Biological Process | GO:0019373 | epoxygenase P450 pathway |
| Biological Process | GO:0042180 | ketone metabolic process |
| Biological Process | GO:1904010 | response to Aroclor 1254 |
| Biological Process | GO:0009617 | response to bacterium |
| Biological Process | GO:0008202 | steroid metabolic process |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.