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Overview

Uniprot IDP13221
Protein NameAspartate aminotransferase, cytoplasmic
Gene NameGot1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
214 KQIAAVMKRRFLFPF
290 RVLSQMEKIVRITWS
325 KEWKGNVKTMADRIL
33 RDDPDPRKVNLGVGA

Function

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain

Protein Sequence

10 MAPPSFFAQV 20 PQAPPVLVFK 30 LIADFRDDPD 40 PRKVNLGVGA 50 YRTDDSQPWV 60 LPVVRKVEQK 70 IANDHSLNHE 80 YLPILGLAEF 90 RSCASQLVLG 100 DNSPALRENR 110 VGGVQSLGGT 120 GALRIGADFL 130 GRWYNGTDNK 140 NTPVYVSSPT 150 WENHNGVFSA 160 AGFKDIRSYR 170 YWDAEKRGLD 180 LQGFLNDLEN 190 APEFSIFVLH 200 ACAHNPTGTD 210 PTEEEWKQIA 220 AVMKRRFLFP 230 FFDSAYQGFA 240 SGDLEKDAWA 250 IRYFVSEGFE 260 LFCAQSFSKN 270 FGLYNERVGN 280 LTVVGKEHDS 290 VLRVLSQMEK 300 IVRITWSNPP 310 AQGARIVATT 320 LSNPELFKEW 330 KGNVKTMADR 340 ILTMRSELRA 350 RLEALKTPGT 360 WSHITEQIGM 370 FSFTGLNPKQ 380 VEYLVNEKHI 390 YLMPSGRINM 400 CGLTTKNLDY 410 VATSINEAVT KFQ

Gene Ontology

Classification GO ID Description
Biological Process GO:0097054 L-glutamate biosynthetic process
Cellular Component GO:0043679 axon terminus
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0120554 2-aminobutanoate transaminase activity
Molecular Function GO:0031406 carboxylic acid binding
Molecular Function GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
Molecular Function GO:0047801 L-cysteine transaminase activity
Molecular Function GO:0004609 phosphatidylserine decarboxylase activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006531 aspartate metabolic process
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0043648 dicarboxylic acid metabolic process
Biological Process GO:0055089 fatty acid homeostasis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0006114 glycerol biosynthetic process
Biological Process GO:0006532 L-aspartate biosynthetic process
Biological Process GO:0006533 L-aspartate catabolic process
Biological Process GO:0019550 L-glutamate catabolic process to aspartate
Biological Process GO:0043490 malate-aspartate shuttle
Biological Process GO:0032966 negative regulation of collagen biosynthetic process
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0051902 negative regulation of mitochondrial depolarization
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0006107 oxaloacetate metabolic process
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:0009743 response to carbohydrate
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0035902 response to immobilization stress
Biological Process GO:1990267 response to transition metal nanoparticle
Biological Process GO:0060290 transdifferentiation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.