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Overview

Uniprot IDP13233
Protein Name2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene NameCnp
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
101 ADFSEEYKRLDEDLA
161 RLDCAQLKEKNQWQL
163 DCAQLKEKNQWQLSL
174 QLSLDDLKKLKPGLE
175 LSLDDLKKLKPGLEK
177 LDDLKKLKPGLEKDF
196 FGWFLTKKSSETLRK
203 KSSETLRKAGQVFLE
232 FISGDEPKEKLDLVS
234 SGDEPKEKLDLVSYF
243 DLVSYFGKRPPGVLH
254 GVLHCTTKFCDYGKA
260 TKFCDYGKATGAEEY
29 SSSGAKDKPELQFPF
370 VGELPRGKLYSLGKG
376 GKLYSLGKGRWMLSL
390 LAKKMEVKAIFTGYY
399 IFTGYYGKGKPVPVH
401 TGYYGKGKPVPVHGS
63 RGLPGSGKSTLARLI
8 MSTSFARKSHTFLPK
87 MVSADAYKIIPGSRA

Function

Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions

Protein Sequence

10 MSTSFARKSH 20 TFLPKIFFRK 30 MSSSGAKDKP 40 ELQFPFLQDE 50 DTVATLHECK 60 TLFILRGLPG 70 SGKSTLARLI 80 VEKYHNGTKM 90 VSADAYKIIP 100 GSRADFSEEY 110 KRLDEDLAGY 120 CRRDIRVLVL 130 DDTNHERERL 140 DQLFEMADQY 150 QYQVVLVEPK 160 TAWRLDCAQL 170 KEKNQWQLSL 180 DDLKKLKPGL 190 EKDFLPLYFG 200 WFLTKKSSET 210 LRKAGQVFLE 220 ELGNHKAFKK 230 ELRHFISGDE 240 PKEKLDLVSY 250 FGKRPPGVLH 260 CTTKFCDYGK 270 ATGAEEYAQQ 280 DVVRRSYGKA 290 FKLSISALFV 300 TPKTAGAQVV 310 LNEQELQLWP 320 SDLDKPSSSE 330 SLPPGSRAHV 340 TLGCAADVQP 350 VQTGLDLLEI 360 LQQVKGGSQG 370 EEVGELPRGK 380 LYSLGKGRWM 390 LSLAKKMEVK 400 AIFTGYYGKG 410 KPVPVHGSRK 420 GGAMQICTII

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005902 microvillus
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0035748 myelin sheath abaxonal region
Cellular Component GO:0035749 myelin sheath adaxonal region
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0031143 pseudopodium
Molecular Function GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Molecular Function GO:0030551 cyclic nucleotide binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0007409 axonogenesis
Biological Process GO:0009214 cyclic nucleotide catabolic process
Biological Process GO:0030900 forebrain development
Biological Process GO:0048709 oligodendrocyte differentiation
Biological Process GO:0046902 regulation of mitochondrial membrane permeability
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0009636 response to toxic substance

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.