Search Results
Overview
| Uniprot ID | P13264 |
|---|---|
| Protein Name | Glutaminase kidney isoform, mitochondrial |
| Gene Name | Gls |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | MVAAGDNKVKQGLLP |
| 169 | HKFITALKSTGLRTS |
| 181 | RTSDPRLKECMDMLR |
| 250 | AKKQSGGKVADYIPQ |
| 316 | YVHRYVGKEPSGLRF |
| 621 | CKVNPFPKDRWNNTP |
Function
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain
Protein Sequence
10
MMRLRGSAML
20
RELLLRPPAA
30
VGGVLRRTQP
40
LGTLCRRPRG
50
GSRPAAGLVA
60
AARLHPWWGG
70
GGRAKGPGSG
80
GLSSSPSEIL
90
QELGKGGTPP
100
QQQQQQQQQP
110
GASPPAAPGP
120
KDSPGETDAF
130
GNSEGKEMVA
140
AGDNKVKQGL
150
LPSLEDLLFY
160
TIAEGQEKIP
170
VHKFITALKS
180
TGLRTSDPRL
190
KECMDMLRLT
200
LQTTSDGVML
210
DKDLFKKCVQ
220
SNIVLLTQAF
230
RRKFVIPDFM
240
SFTSHIDELY
250
ESAKKQSGGK
260
VADYIPQLAK
270
FSPDLWGVSV
280
CTVDGQRHSI
290
GDTKVPFCLQ
300
SCVKPLKYAI
310
AVNDLGTEYV
320
HRYVGKEPSG
330
LRFNKLFLNE
340
DDKPHNPMVN
350
AGAIVVTSLI
360
KQGVNNAEKF
370
DYVMQFLNKM
380
AGNEYVGFSN
390
ATFQSERESG
400
DRNFAIGYYL
410
KEKKCFPEGT
420
DMVGILDFYF
430
QLCSIEVTCE
440
SASVMAATLA
450
NGGFCPITGE
460
RVLSPEAVRN
470
TLSLMHSCGM
480
YDFSGQFAFH
490
VGLPAKSGVA
500
GGILLVVPNV
510
MGMMCWSPPL
520
DKMGNSVKGI
530
HFCHDLVSLC
540
NFHNYDNLRH
550
FAKKLDPRRE
560
GGDQRVKSVI
570
NLLFAAYTGD
580
VSALRRFALS
590
AMDMEQRDYD
600
SRTALHVAAA
610
EGHVEVVKFL
620
LEACKVNPFP
630
KDRWNNTPMD
640
EALHFGHHDV
650
FKILQEYQVQ
660
YTPQGDSDDG
670
KENQTVHKNL
DGLL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0004359 | glutaminase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0006537 | glutamate biosynthetic process |
| Biological Process | GO:0090461 | intracellular glutamate homeostasis |
| Biological Process | GO:0006543 | L-glutamine catabolic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0002087 | regulation of respiratory gaseous exchange by nervous system process |
| Biological Process | GO:0001967 | suckling behavior |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.