Search Results
Overview
| Uniprot ID | P13383 |
|---|---|
| Protein Name | Nucleolin |
| Gene Name | Ncl |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | KKAVTPAKVVPTPGK |
| 109 | KVVPTPGKKGAAQAK |
| 116 | KKGAAQAKALVPTPG |
| 124 | ALVPTPGKKGAVTPA |
| 231 | KGKKTPAKVVPVKAK |
| 471 | SLYYTGEKGQRQERT |
| 480 | QRQERTGKNSTWSGE |
| 575 | NARSQPSKTLFVKGL |
| 63 | ATTTPAKKVVVSQTK |
| 71 | VVVSQTKKAAVPTPA |
| 79 | AAVPTPAKKAAVTPG |
| 80 | AVPTPAKKAAVTPGK |
Function
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity)
Protein Sequence
10
MVKLAKAGKT
20
HGESKKMAPP
30
PKEVEEDSED
40
EEMSEDEDDS
50
SGEEEVVIPQ
60
KKGKKATTTP
70
AKKVVVSQTK
80
KAAVPTPAKK
90
AAVTPGKKAA
100
ATPAKKAVTP
110
AKVVPTPGKK
120
GAAQAKALVP
130
TPGKKGAVTP
140
AKGAKNGKNA
150
KKEDSDEDED
160
EEDEDDSDED
170
EDEEDEFEPP
180
VVKGVKPAKA
190
APAAPASEDE
200
DEEDDDDEDD
210
DDDDEEEEEE
220
DDSEEEVMEI
230
TPAKGKKTPA
240
KVVPVKAKSV
250
AEEEEDDEDD
260
EDEEEDEDEE
270
DEEDDEDEDE
280
EEEEEPVKAA
290
PGKRKKEMTK
300
QKEAPEAKKQ
310
KIEGSEPTTP
320
FNLFIGNLNP
330
NKSVAELKVA
340
ISELFAKNDL
350
AAVDVRTGTN
360
RKFGYVDFES
370
AEDLEKALEL
380
TGLKVFGNEI
390
KLEKPKGRDS
400
KKVRAARTLL
410
AKNLSFNITE
420
DELKEVFEDA
430
VEIRLVSQDG
440
RSKGIAYIEF
450
KSEADAEKNL
460
EEKQGAEIDG
470
RSVSLYYTGE
480
KGQRQERTGK
490
NSTWSGESKT
500
LVLSNLSYSA
510
TEETLQEVFE
520
KATFIKVPQN
530
PHGKSKGYAF
540
IEFASFEDAK
550
EALNSCNKME
560
IEGRTIRLEL
570
QGPRGSPNAR
580
SQPSKTLFVK
590
GLSEDTTEET
600
LKESFEGSVR
610
ARIVTDRETG
620
SSKGFGFVDF
630
NSEEDAKAAK
640
EAMEDGEIDG
650
NKVTLDWAKP
660
KGEGGFGGRG
670
GGRGGFGGRG
680
GGRGGRGGFG
690
GRGRGGFGGR
700
GGFRGGRGGG
710
GDFKPQGKKT
KFE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0001651 | dense fibrillar component |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0044547 | DNA topoisomerase binding |
| Molecular Function | GO:1990631 | ErbB-4 class receptor binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0043560 | insulin receptor substrate binding |
| Molecular Function | GO:0043236 | laminin binding |
| Molecular Function | GO:0048027 | mRNA 5'-UTR binding |
| Molecular Function | GO:0042731 | PH domain binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0042134 | rRNA primary transcript binding |
| Molecular Function | GO:0035368 | selenocysteine insertion sequence binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0042162 | telomeric DNA binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:1901838 | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:2000232 | regulation of rRNA processing |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.