Search Results
Overview
| Uniprot ID | P13412 |
|---|---|
| Protein Name | Troponin I, fast skeletal muscle |
| Gene Name | Tnni2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | MSADAMLKALLGSKH |
| 132 | ALLGSKHKVCMDLRA |
| 168 | WRKNIEEKSGMEGRK |
| 32 | IAATELEKEESRRES |
| 71 | LCKQLHAKIDVAEEE |
| 85 | EKYDMEVKVQKSSKE |
| 91 | VKVQKSSKELEDMNQ |
| 99 | ELEDMNQKLFDLRGK |
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Protein Sequence
10
MGDEEKRNRA
20
ITARRQHLKS
30
VMLQIAATEL
40
EKEESRRESE
50
KENYLSEHCP
60
PLHIPGSMSE
70
VQELCKQLHA
80
KIDVAEEEKY
90
DMEVKVQKSS
100
KELEDMNQKL
110
FDLRGKFKRP
120
PLRRVRMSAD
130
AMLKALLGSK
140
HKVCMDLRAN
150
LKQVKKEDTE
160
KERDLRDVGD
170
WRKNIEEKSG
180
MEGRKKMFES
ES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0031014 | troponin T binding |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0003009 | skeletal muscle contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.