Overview
| Uniprot ID | P13489 |
|---|
| Protein Name | Ribonuclease inhibitor |
|---|
| Gene Name | RNH1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 46 |
GLTEARCKDISSALR |
Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625)
Protein Sequence
10
MSLDIQSLDI
20
QCEELSDARW
30
AELLPLLQQC
40
QVVRLDDCGL
50
TEARCKDISS
60
ALRVNPALAE
70
LNLRSNELGD
80
VGVHCVLQGL
90
QTPSCKIQKL
100
SLQNCCLTGA
110
GCGVLSSTLR
120
TLPTLQELHL
130
SDNLLGDAGL
140
QLLCEGLLDP
150
QCRLEKLQLE
160
YCSLSAASCE
170
PLASVLRAKP
180
DFKELTVSNN
190
DINEAGVRVL
200
CQGLKDSPCQ
210
LEALKLESCG
220
VTSDNCRDLC
230
GIVASKASLR
240
ELALGSNKLG
250
DVGMAELCPG
260
LLHPSSRLRT
270
LWIWECGITA
280
KGCGDLCRVL
290
RAKESLKELS
300
LAGNELGDEG
310
ARLLCETLLE
320
PGCQLESLWV
330
KSCSFTAACC
340
SHFSSVLAQN
350
RFLLELQISN
360
NRLEDAGVRE
370
LCQGLGQPGS
380
VLRVLWLADC
390
DVSDSSCSSL
400
AATLLANHSL
410
RELDLSNNCL
420
GDAGILQLVE
430
SVRQPGCLLE
440
QLVLYDIYWS
450
EEMEDRLQAL
460
EKDKPSLRVI
S
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0032311 |
angiogenin-PRI complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0008428 |
ribonuclease inhibitor activity |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0006402 |
mRNA catabolic process |
| Biological Process |
GO:0045765 |
regulation of angiogenesis |
| Biological Process |
GO:0034315 |
regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:0036416 |
tRNA stabilization |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.