Search Results
Overview
| Uniprot ID | P13597 |
|---|---|
| Protein Name | Intercellular adhesion molecule 1 |
| Gene Name | Icam1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 421 | EGSQQTLKCQAWGNP |
Function
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1
Protein Sequence
10
MASTRAKPTL
20
PLLLALVTVV
30
IPGPGDAQVS
40
IHPREAFLPQ
50
GGSVQVNCSS
60
SCKEDLSLGL
70
ETQWLKDELE
80
SGPNWKLFEL
90
SEIGEDSSPL
100
CFENCGTVQS
110
SASATITVYS
120
FPESVELRPL
130
PAWQQVGKDL
140
TLRCHVDGGA
150
PRTQLSAVLL
160
RGEEILSRQP
170
VGGHPKDPKE
180
ITFTVLASRG
190
DHGANFSCRT
200
ELDLRPQGLA
210
LFSNVSEARS
220
LRTFDLPATI
230
PKLDTPDLLE
240
VGTQQKLFCS
250
LEGLFPASEA
260
RIYLELGGQM
270
PTQESTNSSD
280
SVSATALVEV
290
TEEFDRTLPL
300
RCVLELADQI
310
LETQRTLTVY
320
NFSAPVLTLS
330
QLEVSEGSQV
340
TVKCEAHSGS
350
KVVLLSGVEP
360
RPPTPQVQFT
370
LNASSEDHKR
380
SFFCSAALEV
390
AGKFLFKNQT
400
LELHVLYGPR
410
LDETDCLGNW
420
TWQEGSQQTL
430
KCQAWGNPSP
440
KMTCRRKADG
450
ALLPIGVVKS
460
VKQEMNGTYV
470
CHAFSSHGNV
480
TRNVYLTVLY
490
HSQNNWTIII
500
LVPVLLVIVG
510
LVMAASYVYN
520
RQRKIRIYKL
530
QKAQEEAIKL
KGQAPPP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0033627 | cell adhesion mediated by integrin |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0033631 | cell-cell adhesion mediated by integrin |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
| Biological Process | GO:0097368 | establishment of Sertoli cell barrier |
| Biological Process | GO:0061756 | leukocyte adhesion to vascular endothelial cell |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0022614 | membrane to membrane docking |
| Biological Process | GO:0051926 | negative regulation of calcium ion transport |
| Biological Process | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0002693 | positive regulation of cellular extravasation |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:0045907 | positive regulation of vasoconstriction |
| Biological Process | GO:0046813 | receptor-mediated virion attachment to host cell |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:1900027 | regulation of ruffle assembly |
| Biological Process | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| Biological Process | GO:0002457 | T cell antigen processing and presentation |
| Biological Process | GO:0072683 | T cell extravasation |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Biological Process | GO:0002438 | acute inflammatory response to antigenic stimulus |
| Biological Process | GO:0044406 | adhesion of symbiont to host |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.