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Overview

Uniprot IDP13637
Protein NameSodium/potassium-transporting ATPase subunit alpha-3
Gene NameATP1A3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
424 LCNRAVFKGGQDNIP
434 QDNIPVLKRDVAGDA
44 SVEEVCRKYNTDCVQ
466 LMRERNKKVAEIPFN
477 IPFNSTNKYQLSIHE
57 VQGLTHSKAQEILAR
651 QVNPRDAKACVIHGT

Function

Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:36075933). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes (By similarity). In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933)

Protein Sequence

10 MGDKKDDKDS 20 PKKNKGKERR 30 DLDDLKKEVA 40 MTEHKMSVEE 50 VCRKYNTDCV 60 QGLTHSKAQE 70 ILARDGPNAL 80 TPPPTTPEWV 90 KFCRQLFGGF 100 SILLWIGAIL 110 CFLAYGIQAG 120 TEDDPSGDNL 130 YLGIVLAAVV 140 IITGCFSYYQ 150 EAKSSKIMES 160 FKNMVPQQAL 170 VIREGEKMQV 180 NAEEVVVGDL 190 VEIKGGDRVP 200 ADLRIISAHG 210 CKVDNSSLTG 220 ESEPQTRSPD 230 CTHDNPLETR 240 NITFFSTNCV 250 EGTARGVVVA 260 TGDRTVMGRI 270 ATLASGLEVG 280 KTPIAIEIEH 290 FIQLITGVAV 300 FLGVSFFILS 310 LILGYTWLEA 320 VIFLIGIIVA 330 NVPEGLLATV 340 TVCLTLTAKR 350 MARKNCLVKN 360 LEAVETLGST 370 STICSDKTGT 380 LTQNRMTVAH 390 MWFDNQIHEA 400 DTTEDQSGTS 410 FDKSSHTWVA 420 LSHIAGLCNR 430 AVFKGGQDNI 440 PVLKRDVAGD 450 ASESALLKCI 460 ELSSGSVKLM 470 RERNKKVAEI 480 PFNSTNKYQL 490 SIHETEDPND 500 NRYLLVMKGA 510 PERILDRCST 520 ILLQGKEQPL 530 DEEMKEAFQN 540 AYLELGGLGE 550 RVLGFCHYYL 560 PEEQFPKGFA 570 FDCDDVNFTT 580 DNLCFVGLMS 590 MIDPPRAAVP 600 DAVGKCRSAG 610 IKVIMVTGDH 620 PITAKAIAKG 630 VGIISEGNET 640 VEDIAARLNI 650 PVSQVNPRDA 660 KACVIHGTDL 670 KDFTSEQIDE 680 ILQNHTEIVF 690 ARTSPQQKLI 700 IVEGCQRQGA 710 IVAVTGDGVN 720 DSPALKKADI 730 GVAMGIAGSD 740 VSKQAADMIL 750 LDDNFASIVT 760 GVEEGRLIFD 770 NLKKSIAYTL 780 TSNIPEITPF 790 LLFIMANIPL 800 PLGTITILCI 810 DLGTDMVPAI 820 SLAYEAAESD 830 IMKRQPRNPR 840 TDKLVNERLI 850 SMAYGQIGMI 860 QALGGFFSYF 870 VILAENGFLP 880 GNLVGIRLNW 890 DDRTVNDLED 900 SYGQQWTYEQ 910 RKVVEFTCHT 920 AFFVSIVVVQ 930 WADLIICKTR 940 RNSVFQQGMK 950 NKILIFGLFE 960 ETALAAFLSY 970 CPGMDVALRM 980 YPLKPSWWFC 990 AFPYSFLIFV 1000 YDEIRKLILR 1010 RNPGGWVEKE TYY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0098984 neuron to neuron synapse
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0032809 neuronal cell body membrane
Cellular Component GO:0031090 organelle membrane
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0060342 photoreceptor inner segment membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005890 sodium:potassium-exchanging ATPase complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005391 P-type sodium:potassium-exchanging transporter activity
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:1990239 steroid hormone binding
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071383 cellular response to steroid hormone stimulus
Biological Process GO:0030007 intracellular potassium ion homeostasis
Biological Process GO:0006883 intracellular sodium ion homeostasis
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0060075 regulation of resting membrane potential
Biological Process GO:1903416 response to glycoside
Biological Process GO:0036376 sodium ion export across plasma membrane

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.