Search Results
Overview
| Uniprot ID | P13638 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit beta-2 |
| Gene Name | Atp1b2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 276 | ATDDERDKFAARVAF |
| 8 | MVIQKEKKSCGQVVE |
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Protein Sequence
10
MVIQKEKKSC
20
GQVVEEWKEF
30
VWNPRTHQFM
40
GRTGTSWAFI
50
LLFYLVFYGF
60
LTAMFTLTMW
70
VMLQTVSDHT
80
PKYQDRLATP
90
GLMIRPKTEN
100
LDVIVNISDT
110
ESWDQHVQKL
120
NKFLEPYNDS
130
IQAQKNDVCR
140
PGRYYEQPDN
150
GVLNYPKRAC
160
QFNRTQLGNC
170
SGIGDPTHYG
180
YSTGQPCVFI
190
KMNRVINFYA
200
GANQSMNVTC
210
VGKKDEDAEN
220
LGHFIMFPAN
230
GNIDLMYFPY
240
YGKKFHVNYT
250
QPLVAVKFLN
260
VTPNVEVNVE
270
CRINAANIAT
280
DDERDKFAAR
290
VAFKLRINKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0097450 | astrocyte end-foot |
| Cellular Component | GO:0097449 | astrocyte projection |
| Cellular Component | GO:0044298 | cell body membrane |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0031253 | cell projection membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0098984 | neuron to neuron synapse |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0141109 | transporter activator activity |
| Biological Process | GO:0031589 | cell-substrate adhesion |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0021670 | lateral ventricle development |
| Biological Process | GO:0086009 | membrane repolarization |
| Biological Process | GO:0061744 | motor behavior |
| Biological Process | GO:1903976 | negative regulation of glial cell migration |
| Biological Process | GO:0021944 | neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration |
| Biological Process | GO:0045494 | photoreceptor cell maintenance |
| Biological Process | GO:0120036 | plasma membrane bounded cell projection organization |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:1903288 | positive regulation of potassium ion import across plasma membrane |
| Biological Process | GO:1903278 | positive regulation of sodium ion export across plasma membrane |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0001895 | retina homeostasis |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Biological Process | GO:0021678 | third ventricle development |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.