Search Results

Overview

Uniprot IDP13645
Protein NameKeratin, type I cytoskeletal 10
Gene NameKRT10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
163 RLASYLDKVRALEES
177 SNYELEGKIKEWYEK
179 YELEGKIKEWYEKHG
201 RDYSKYYKTIDDLKN
207 YKTIDDLKNQILNLT
237 AADDFRLKYENEVAL
266 LDELTLTKADLEMQI
285 EELAYLKKNHEEEMK
334 QLAEQNRKDAEAWFN
343 AEAWFNEKSKELTTE
345 AWFNEKSKELTTEID
362 IEQISSYKSEITELR
386 LQSQLALKQSLEASL
40 SLRISSSKGSLGGGF
439 YQQLLDIKIRLENEI

Function

Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that support terminal differentiation, mechanical resilience, and epidermal barrier formation

Protein Sequence

10 MSVRYSSSKH 20 YSSSRSGGGG 30 GGGGCGGGGG 40 VSSLRISSSK 50 GSLGGGFSSG 60 GFSGGSFSRG 70 SSGGGCFGGS 80 SGGYGGLGGF 90 GGGSFRGSYG 100 SSSFGGSYGG 110 IFGGGSFGGG 120 SFGGGSFGGG 130 GFGGGGFGGG 140 FGGGFGGDGG 150 LLSGNEKVTM 160 QNLNDRLASY 170 LDKVRALEES 180 NYELEGKIKE 190 WYEKHGNSHQ 200 GEPRDYSKYY 210 KTIDDLKNQI 220 LNLTTDNANI 230 LLQIDNARLA 240 ADDFRLKYEN 250 EVALRQSVEA 260 DINGLRRVLD 270 ELTLTKADLE 280 MQIESLTEEL 290 AYLKKNHEEE 300 MKDLRNVSTG 310 DVNVEMNAAP 320 GVDLTQLLNN 330 MRSQYEQLAE 340 QNRKDAEAWF 350 NEKSKELTTE 360 IDNNIEQISS 370 YKSEITELRR 380 NVQALEIELQ 390 SQLALKQSLE 400 ASLAETEGRY 410 CVQLSQIQAQ 420 ISALEEQLQQ 430 IRAETECQNT 440 EYQQLLDIKI 450 RLENEIQTYR 460 SLLEGEGSSG 470 GGGRGGGSFG 480 GGYGGGSSGG 490 GSSGGGHGGG 500 HGGSSGGGYG 510 GGSSGGGSSG 520 GGYGGGSSSG 530 GHGGSSSGGY 540 GGGSSGGGGG 550 GYGGGSSGGG 560 SSSGGGYGGG 570 SSSGGHKSSS 580 SGSVGESSSK GPRY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0030280 structural constituent of skin epidermis
Biological Process GO:0070268 cornification
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0002009 morphogenesis of an epithelium
Biological Process GO:0045684 positive regulation of epidermis development
Biological Process GO:0051290 protein heterotetramerization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.