Search Results

Overview

Uniprot IDP13667
Protein NameProtein disulfide-isomerase A4
Gene NamePDIA4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
111 IANILKDKDPPIPVA
119 DPPIPVAKIDATSAS
141 VSGYPTIKILKKGQA
145 PTIKILKKGQAVDYE
163 TQEEIVAKVREVSQP
211 PWCGHCKKLAPEYEK
221 PEYEKAAKELSKRSP
234 SPPIPLAKVDATAET
245 TAETDLAKRFDVSGY
272 DYNGPREKYGIVDYM
294 SKEILTLKQVQEFLK
335 NNLREDYKFHHTFST
346 TFSTEIAKFLKVSQG
349 TEIAKFLKVSQGQLV
362 LVVMQPEKFQSKYEP
366 QPEKFQSKYEPRSHM
386 STQDSAIKDFVLKYA
401 LPLVGHRKVSNDAKR
437 ATQFWRSKVLEVAKD
485 ILDESGKKFAMEPEE
506 REFVTAFKKGKLKPV
509 VTAFKKGKLKPVIKS
515 GKLKPVIKSQPVPKN
521 IKSQPVPKNNKGPVK
524 QPVPKNNKGPVKVVV
528 KNNKGPVKVVVGKTF
533 PVKVVVGKTFDSIVM
543 DSIVMDPKKDVLIEF
544 SIVMDPKKDVLIEFY
570 PVYNSLAKKYKGQKG
576 AKKYKGQKGLVIAKM
582 QKGLVIAKMDATAND
611 YFAPSGDKKNPVKFE
616 GDKKNPVKFEGGDRD
629 RDLEHLSKFIEEHAT
637 FIEEHATKLSRTKEE

Function

No function data available.

Protein Sequence

10 MRPRKAFLLL 20 LLLGLVQLLA 30 VAGAEGPDED 40 SSNRENAIED 50 EEEEEEEDDD 60 EEEDDLEVKE 70 ENGVLVLNDA 80 NFDNFVADKD 90 TVLLEFYAPW 100 CGHCKQFAPE 110 YEKIANILKD 120 KDPPIPVAKI 130 DATSASVLAS 140 RFDVSGYPTI 150 KILKKGQAVD 160 YEGSRTQEEI 170 VAKVREVSQP 180 DWTPPPEVTL 190 VLTKENFDEV 200 VNDADIILVE 210 FYAPWCGHCK 220 KLAPEYEKAA 230 KELSKRSPPI 240 PLAKVDATAE 250 TDLAKRFDVS 260 GYPTLKIFRK 270 GRPYDYNGPR 280 EKYGIVDYMI 290 EQSGPPSKEI 300 LTLKQVQEFL 310 KDGDDVIIIG 320 VFKGESDPAY 330 QQYQDAANNL 340 REDYKFHHTF 350 STEIAKFLKV 360 SQGQLVVMQP 370 EKFQSKYEPR 380 SHMMDVQGST 390 QDSAIKDFVL 400 KYALPLVGHR 410 KVSNDAKRYT 420 RRPLVVVYYS 430 VDFSFDYRAA 440 TQFWRSKVLE 450 VAKDFPEYTF 460 AIADEEDYAG 470 EVKDLGLSES 480 GEDVNAAILD 490 ESGKKFAMEP 500 EEFDSDTLRE 510 FVTAFKKGKL 520 KPVIKSQPVP 530 KNNKGPVKVV 540 VGKTFDSIVM 550 DPKKDVLIEF 560 YAPWCGHCKQ 570 LEPVYNSLAK 580 KYKGQKGLVI 590 AKMDATANDV 600 PSDRYKVEGF 610 PTIYFAPSGD 620 KKNPVKFEGG 630 DRDLEHLSKF 640 IEEHATKLSR TKEEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042470 melanosome
Molecular Function GO:0003756 protein disulfide isomerase activity
Molecular Function GO:0015035 protein-disulfide reductase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006457 protein folding
Biological Process GO:0009306 protein secretion
Biological Process GO:0034976 response to endoplasmic reticulum stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.