Search Results
Overview
| Uniprot ID | P13668 |
|---|---|
| Protein Name | Stathmin |
| Gene Name | Stmn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | FSKMAEEKLTHKMEA |
| 104 | AEEKLTHKMEANKEN |
| 109 | THKMEANKENREAQM |
| 119 | REAQMAAKLERLREK |
| 128 | ERLREKDKHVEEVRK |
| 13 | IQVKELEKRASGQAF |
| 137 | VEEVRKNKESKDPAD |
| 29 | LILSPRSKESVPEFP |
| 41 | EFPLSPPKKKDLSLE |
| 43 | PLSPPKKKDLSLEEI |
| 52 | LSLEEIQKKLEAAEE |
| 53 | SLEEIQKKLEAAEER |
| 62 | EAAEERRKSHEAEVL |
| 70 | SHEAEVLKQLAEKRE |
| 80 | AEKREHEKEVLQKAI |
| 9 | ASSDIQVKELEKRAS |
Function
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0043005 | neuron projection |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0007019 | microtubule depolymerization |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| Biological Process | GO:0009615 | response to virus |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.