Search Results

Overview

Uniprot IDP13671
Protein NameComplement component C6
Gene NameC6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
308 QAIQASHKKDSSFIR
706 CQRTECIKPVVQEVL

Function

Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22267737, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328, PubMed:39914456, PubMed:39814882). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291)

Protein Sequence

10 MARRSVLYFI 20 LLNALINKGQ 30 ACFCDHYAWT 40 QWTSCSKTCN 50 SGTQSRHRQI 60 VVDKYYQENF 70 CEQICSKQET 80 RECNWQRCPI 90 NCLLGDFGPW 100 SDCDPCIEKQ 110 SKVRSVLRPS 120 QFGGQPCTAP 130 LVAFQPCIPS 140 KLCKIEEADC 150 KNKFRCDSGR 160 CIARKLECNG 170 ENDCGDNSDE 180 RDCGRTKAVC 190 TRKYNPIPSV 200 QLMGNGFHFL 210 AGEPRGEVLD 220 NSFTGGICKT 230 VKSSRTSNPY 240 RVPANLENVG 250 FEVQTAEDDL 260 KTDFYKDLTS 270 LGHNENQQGS 280 FSSQGGSSFS 290 VPIFYSSKRS 300 ENINHNSAFK 310 QAIQASHKKD 320 SSFIRIHKVM 330 KVLNFTTKAK 340 DLHLSDVFLK 350 ALNHLPLEYN 360 SALYSRIFDD 370 FGTHYFTSGS 380 LGGVYDLLYQ 390 FSSEELKNSG 400 LTEEEAKHCV 410 RIETKKRVLF 420 AKKTKVEHRC 430 TTNKLSEKHE 440 GSFIQGAEKS 450 ISLIRGGRSE 460 YGAALAWEKG 470 SSGLEEKTFS 480 EWLESVKENP 490 AVIDFELAPI 500 VDLVRNIPCA 510 VTKRNNLRKA 520 LQEYAAKFDP 530 CQCAPCPNNG 540 RPTLSGTECL 550 CVCQSGTYGE 560 NCEKQSPDYK 570 SNAVDGQWGC 580 WSSWSTCDAT 590 YKRSRTRECN 600 NPAPQRGGKR 610 CEGEKRQEED 620 CTFSIMENNG 630 QPCINDDEEM 640 KEVDLPEIEA 650 DSGCPQPVPP 660 ENGFIRNEKQ 670 LYLVGEDVEI 680 SCLTGFETVG 690 YQYFRCLPDG 700 TWRQGDVECQ 710 RTECIKPVVQ 720 EVLTITPFQR 730 LYRIGESIEL 740 TCPKGFVVAG 750 PSRYTCQGNS 760 WTPPISNSLT 770 CEKDTLTKLK 780 GHCQLGQKQS 790 GSECICMSPE 800 EDCSHHSEDL 810 CVFDTDSNDY 820 FTSPACKFLA 830 EKCLNNQQLH 840 FLHIGSCQDG 850 RQLEWGLERT 860 RLSSNSTKKE 870 SCGYDTCYDW 880 EKCSASTSKC 890 VCLLPPQCFK 900 GGNQLYCVKM 910 GSSTSEKTLN 920 ICEVGTIRCA 930 NRKMEILHPG KCLA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005579 membrane attack complex
Cellular Component GO:0044218 other organism cell membrane
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0006956 complement activation
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0160257 complement activation, GZMK pathway
Biological Process GO:0031640 killing of cells of another organism
Biological Process GO:0001970 positive regulation of activation of membrane attack complex
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0050778 positive regulation of immune response
Biological Process GO:0055085 transmembrane transport

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.