Search Results
Overview
| Uniprot ID | P13693 |
|---|---|
| Protein Name | Translationally-controlled tumor protein |
| Gene Name | TPT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | EQRPERVKPFMTGAA |
Function
Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344)
Protein Sequence
10
MIIYRDLISH
20
DEMFSDIYKI
30
REIADGLCLE
40
VEGKMVSRTE
50
GNIDDSLIGG
60
NASAEGPEGE
70
GTESTVITGV
80
DIVMNHHLQE
90
TSFTKEAYKK
100
YIKDYMKSIK
110
GKLEEQRPER
120
VKPFMTGAAE
130
QIKHILANFK
140
NYQFFIGENM
150
NPDGMVALLD
160
YREDGVTPYM
170
IFFKDGLEME
KC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2000384 | negative regulation of ectoderm development |
| Biological Process | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0019827 | stem cell population maintenance |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.