Search Results
Overview
| Uniprot ID | P13697 |
|---|---|
| Protein Name | NADP-dependent malic enzyme |
| Gene Name | Me1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 351 | RASLTEEKEVFAHEH |
Function
Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate
Protein Sequence
10
MDPRAPRRRH
20
THQRGYLLTR
30
DPHLNKDLAF
40
TLEERQQLKI
50
HGLLPPCIVN
60
QEIQVLRVIK
70
NFERLNSDFD
80
RYLLLMDLQD
90
RNEKLFYSVL
100
MSNVEKFMPI
110
VYTPTVGLAC
120
QQYSLAFRKP
130
RGLFISIHDK
140
GHIASVLNAW
150
PEDVVKAIVV
160
TDGERILGLG
170
DLGCNGMGIP
180
VGKLALYTAC
190
GGVNPQQCLP
200
ITLDVGTENE
210
ELLKDPLYIG
220
LRHRRVRGPE
230
YDAFLDEFME
240
AASSKYGMNC
250
LIQFEDFANL
260
NAFRLLNKYR
270
NKYCTFNDDI
280
QGTASVAVAG
290
LLAALRITKN
300
KLSDQTVLFQ
310
GAGEAALGIA
320
HLIVMAMEKE
330
GLSKEKARQK
340
IWLVDSKGLI
350
VKGRASLTEE
360
KEVFAHEHEE
370
MKNLEAIVQK
380
IKPTALIGVA
390
AIGGAFTEQI
400
LKDMAAFNER
410
PIIFALSNPT
420
SKAECSAEEC
430
YKVTKGRAIF
440
ASGSPFDPVT
450
LPDGRTLFPG
460
QGNNSYVFPG
470
VALGVVACGL
480
RHINDSVFLT
490
TAEVISQQVS
500
DKHLEEGRLY
510
PPLNTIRDVS
520
LKIAVKIVQD
530
AYKEKMATVY
540
PEPQNKEEFV
550
SSQMYSTNYD
560
QILPDCYSWP
570
EEVQKIQTKV
NQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004473 | malate dehydrogenase (decarboxylating) (NADP+) activity |
| Molecular Function | GO:0004470 | malic enzyme activity |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0008948 | oxaloacetate decarboxylase activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:1902031 | regulation of NADP metabolic process |
| Biological Process | GO:0009725 | response to hormone |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.