Search Results
Overview
| Uniprot ID | P13716 |
|---|---|
| Protein Name | Delta-aminolevulinic acid dehydratase |
| Gene Name | ALAD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 179 | DGRVEAIKEALMAHG |
| 213 | GPFRDAAKSSPAFGD |
Function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0046689 | response to mercury ion |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0003824 | catalytic activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0032791 | lead ion binding |
| Molecular Function | GO:0004655 | porphobilinogen synthase activity |
| Molecular Function | GO:1904854 | proteasome core complex binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071284 | cellular response to lead ion |
| Biological Process | GO:0006784 | heme A biosynthetic process |
| Biological Process | GO:0006785 | heme B biosynthetic process |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:1901799 | negative regulation of proteasomal protein catabolic process |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0006782 | protoporphyrinogen IX biosynthetic process |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0010044 | response to aluminum ion |
| Biological Process | GO:0043200 | response to amino acid |
| Biological Process | GO:0046685 | response to arsenic-containing substance |
| Biological Process | GO:0046686 | response to cadmium ion |
| Biological Process | GO:0032025 | response to cobalt ion |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0070542 | response to fatty acid |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0009635 | response to herbicide |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0010212 | response to ionizing radiation |
| Biological Process | GO:0010039 | response to iron ion |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0051597 | response to methylmercury |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0070541 | response to platinum ion |
| Biological Process | GO:0010269 | response to selenium ion |
| Biological Process | GO:0010266 | response to vitamin B1 |
| Biological Process | GO:0033197 | response to vitamin E |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0010043 | response to zinc ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.