Search Results

Overview

Uniprot IDP13796
Protein NamePlastin-2
Gene NameLCP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
297 STDIKDSKAYYHLLE
444 VDWNRVNKPPYPKLG
449 VNKPPYPKLGGNMKK
542 SSSISSFKDPKISTS
579 ENLNDDEKLNNAKYA
584 DEKLNNAKYAISMAR
82 IKIFHGLKSTDVAKT
88 LKSTDVAKTFRKAIN
97 FRKAINKKEGICAIG

Function

Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403)

Protein Sequence

10 MARGSVSDEE 20 MMELREAFAK 30 VDTDGNGYIS 40 FNELNDLFKA 50 ACLPLPGYRV 60 REITENLMAT 70 GDLDQDGRIS 80 FDEFIKIFHG 90 LKSTDVAKTF 100 RKAINKKEGI 110 CAIGGTSEQS 120 SVGTQHSYSE 130 EEKYAFVNWI 140 NKALENDPDC 150 RHVIPMNPNT 160 NDLFNAVGDG 170 IVLCKMINLS 180 VPDTIDERTI 190 NKKKLTPFTI 200 QENLNLALNS 210 ASAIGCHVVN 220 IGAEDLKEGK 230 PYLVLGLLWQ 240 VIKIGLFADI 250 ELSRNEALIA 260 LLREGESLED 270 LMKLSPEELL 280 LRWANYHLEN 290 AGCNKIGNFS 300 TDIKDSKAYY 310 HLLEQVAPKG 320 DEEGVPAVVI 330 DMSGLREKDD 340 IQRAECMLQQ 350 AERLGCRQFV 360 TATDVVRGNP 370 KLNLAFIANL 380 FNRYPALHKP 390 ENQDIDWGAL 400 EGETREERTF 410 RNWMNSLGVN 420 PRVNHLYSDL 430 SDALVIFQLY 440 EKIKVPVDWN 450 RVNKPPYPKL 460 GGNMKKLENC 470 NYAVELGKNQ 480 AKFSLVGIGG 490 QDLNEGNRTL 500 TLALIWQLMR 510 RYTLNILEEI 520 GGGQKVNDDI 530 IVNWVNETLR 540 EAKKSSSISS 550 FKDPKISTSL 560 PVLDLIDAIQ 570 PGSINYDLLK 580 TENLNDDEKL 590 NNAKYAISMA 600 RKIGARVYAL 610 PEDLVEVNPK 620 MVMTVFACLM GKGMKRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005884 actin filament
Cellular Component GO:0032432 actin filament bundle
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0001891 phagocytic cup
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Cellular Component GO:0032587 ruffle membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005178 integrin binding
Biological Process GO:0051764 actin crosslink formation
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0051639 actin filament network formation
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0016477 cell migration
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0033157 regulation of intracellular protein transport
Biological Process GO:0002286 T cell activation involved in immune response

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.