Search Results

Overview

Uniprot IDP13797
Protein NamePlastin-3
Gene NamePLS3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 FRKAINRKEGICALG
266 ETLEELMKLSPEELL
300 SADIKDSKAYFHLLN
312 LLNQIAPKGQKEGEP
346 SMLQQADKLGCRQFV
459 KLGANMKKLENCNYA
471 NYAVELGKHPAKFSL
52 NMPLPGYKVREIIQK
537 RTLSEAGKSTSIQSF
545 STSIQSFKDKTISSS
91 VKSSDIAKTFRKAIN

Function

Actin-bundling protein

Protein Sequence

10 MDEMATTQIS 20 KDELDELKEA 30 FAKVDLNSNG 40 FICDYELHEL 50 FKEANMPLPG 60 YKVREIIQKL 70 MLDGDRNKDG 80 KISFDEFVYI 90 FQEVKSSDIA 100 KTFRKAINRK 110 EGICALGGTS 120 ELSSEGTQHS 130 YSEEEKYAFV 140 NWINKALEND 150 PDCRHVIPMN 160 PNTDDLFKAV 170 GDGIVLCKMI 180 NLSVPDTIDE 190 RAINKKKLTP 200 FIIQENLNLA 210 LNSASAIGCH 220 VVNIGAEDLR 230 AGKPHLVLGL 240 LWQIIKIGLF 250 ADIELSRNEA 260 LAALLRDGET 270 LEELMKLSPE 280 ELLLRWANFH 290 LENSGWQKIN 300 NFSADIKDSK 310 AYFHLLNQIA 320 PKGQKEGEPR 330 IDINMSGFNE 340 TDDLKRAESM 350 LQQADKLGCR 360 QFVTPADVVS 370 GNPKLNLAFV 380 ANLFNKYPAL 390 TKPENQDIDW 400 TLLEGETREE 410 RTFRNWMNSL 420 GVNPHVNHLY 430 ADLQDALVIL 440 QLYERIKVPV 450 DWSKVNKPPY 460 PKLGANMKKL 470 ENCNYAVELG 480 KHPAKFSLVG 490 IGGQDLNDGN 500 QTLTLALVWQ 510 LMRRYTLNVL 520 EDLGDGQKAN 530 DDIIVNWVNR 540 TLSEAGKSTS 550 IQSFKDKTIS 560 SSLAVVDLID 570 AIQPGCINYD 580 LVKSGNLTED 590 DKHNNAKYAV 600 SMARRIGARV 610 YALPEDLVEV 620 KPKMVMTVFA 630 CLMGRGMKRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Cellular Component GO:0032432 actin filament bundle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031594 neuromuscular junction
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0098699 structural constituent of presynaptic actin cytoskeleton
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0051639 actin filament network formation
Biological Process GO:0060348 bone development
Biological Process GO:0098693 regulation of synaptic vesicle cycle

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.