Overview
| Uniprot ID | P13798 |
|---|
| Protein Name | Acylamino-acid-releasing enzyme |
|---|
| Gene Name | APEH |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 291 |
YVDLIGGKCELLSDD |
Function
Aminopeptidase involved in the degradation of N(alpha)-acylated peptides. Displays exopeptidase activity toward N-formyl and N-acetyl peptides with a preference for dipeptide substrates (By similarity). Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Hydrolyzes N-formylated peptides likely arising from N-terminal proteolytic cleavage of bacterial and mitochondrial proteins. May act sequentially with ACY1 in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate (By similarity). Displays endopeptidase activity involved in the degradation of oxidized and glycated proteins (PubMed:10719179)
Protein Sequence
10
MERQVLLSEP
20
EEAAALYRGL
30
SRQPALSAAC
40
LGPEVTTQYG
50
GQYRTVHTEW
60
TQRDLERMEN
70
IRFCRQYLVF
80
HDGDSVVFAG
90
PAGNSVETRG
100
ELLSRESPSG
110
TMKAVLRKAG
120
GTGPGEEKQF
130
LEVWEKNRKL
140
KSFNLSALEK
150
HGPVYEDDCF
160
GCLSWSHSET
170
HLLYVAEKKR
180
PKAESFFQTK
190
ALDVSASDDE
200
IARLKKPDQA
210
IKGDQFVFYE
220
DWGENMVSKS
230
IPVLCVLDVE
240
SGNISVLEGV
250
PENVSPGQAF
260
WAPGDAGVVF
270
VGWWHEPFRL
280
GIRFCTNRRS
290
ALYYVDLIGG
300
KCELLSDDSL
310
AVSSPRLSPD
320
QCRIVYLQYP
330
SLIPHHQCSQ
340
LCLYDWYTKV
350
TSVVVDVVPR
360
QLGENFSGIY
370
CSLLPLGCWS
380
ADSQRVVFDS
390
AQRSRQDLFA
400
VDTQVGTVTS
410
LTAGGSGGSW
420
KLLTIDQDLM
430
VAQFSTPSLP
440
PTLKVGFLPS
450
AGKEQSVLWV
460
SLEEAEPIPD
470
IHWGIRVLQP
480
PPEQENVQYA
490
GLDFEAILLQ
500
PGSPPDKTQV
510
PMVVMPHGGP
520
HSSFVTAWML
530
FPAMLCKMGF
540
AVLLVNYRGS
550
TGFGQDSILS
560
LPGNVGHQDV
570
KDVQFAVEQV
580
LQEEHFDASH
590
VALMGGSHGG
600
FISCHLIGQY
610
PETYRACVAR
620
NPVINIASML
630
GSTDIPDWCV
640
VEAGFPFSSD
650
CLPDLSVWAE
660
MLDKSPIRYI
670
PQVKTPLLLM
680
LGQEDRRVPF
690
KQGMEYYRAL
700
KTRNVPVRLL
710
LYPKSTHALS
720
EVEVESDSFM
730
NAVLWLRTHL
GS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:1904813 |
ficolin-1-rich granule lumen |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008242 |
omega peptidase activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0004252 |
serine-type endopeptidase activity |
| Biological Process |
GO:0050435 |
amyloid-beta metabolic process |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0006415 |
translational termination |
Reference
PMID: N/A