Search Results

Overview

Uniprot IDP13804
Protein NameElectron transfer flavoprotein subunit alpha, mitochondrial
Gene NameETFA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
139 ISDIIAIKSPDTFVR
158 GNALCTVKCDEKVKV
164 VKCDEKVKVFSVRGT
187 GGSASSEKASSTSPV
206 WLDQKLTKSDRPELT
216 RPELTGAKVVVSGGR
226 VSGGRGLKSGENFKL
294 LAGMKDSKTIVAINK
331 PEMTEILKKK*****
59 SCLVAGTKCDKVAQD
62 VAGTKCDKVAQDLCK
69 KVAQDLCKVAGIAKV
75 CKVAGIAKVLVAQHD

Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842)

Protein Sequence

10 MFRAAAPGQL 20 RRAASLLRFQ 30 STLVIAEHAN 40 DSLAPITLNT 50 ITAATRLGGE 60 VSCLVAGTKC 70 DKVAQDLCKV 80 AGIAKVLVAQ 90 HDVYKGLLPE 100 ELTPLILATQ 110 KQFNYTHICA 120 GASAFGKNLL 130 PRVAAKLEVA 140 PISDIIAIKS 150 PDTFVRTIYA 160 GNALCTVKCD 170 EKVKVFSVRG 180 TSFDAAATSG 190 GSASSEKASS 200 TSPVEISEWL 210 DQKLTKSDRP 220 ELTGAKVVVS 230 GGRGLKSGEN 240 FKLLYDLADQ 250 LHAAVGASRA 260 AVDAGFVPND 270 MQVGQTGKIV 280 APELYIAVGI 290 SGAIQHLAGM 300 KDSKTIVAIN 310 KDPEAPIFQV 320 ADYGIVADLF 330 KVVPEMTEIL KKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045251 electron transfer flavoprotein complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0016491 oxidoreductase activity
Biological Process GO:0009063 amino acid catabolic process
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process GO:0022904 respiratory electron transport chain

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.