Overview
| Uniprot ID | P13866 |
|---|
| Protein Name | Sodium/glucose cotransporter 1 |
|---|
| Gene Name | SLC5A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 631 |
EEKAMKMKMTDTSEK |
Function
Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:34880492, PubMed:35077764, PubMed:8563765, PubMed:37217492). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity) (PubMed:8563765). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690). Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine
Protein Sequence
10
MDSSTWSPKT
20
TAVTRPVETH
30
ELIRNAADIS
40
IIVIYFVVVM
50
AVGLWAMFST
60
NRGTVGGFFL
70
AGRSMVWWPI
80
GASLFASNIG
90
SGHFVGLAGT
100
GAASGIAIGG
110
FEWNALVLVV
120
VLGWLFVPIY
130
IKAGVVTMPE
140
YLRKRFGGQR
150
IQVYLSLLSL
160
LLYIFTKISA
170
DIFSGAIFIN
180
LALGLNLYLA
190
IFLLLAITAL
200
YTITGGLAAV
210
IYTDTLQTVI
220
MLVGSLILTG
230
FAFHEVGGYD
240
AFMEKYMKAI
250
PTIVSDGNTT
260
FQEKCYTPRA
270
DSFHIFRDPL
280
TGDLPWPGFI
290
FGMSILTLWY
300
WCTDQVIVQR
310
CLSAKNMSHV
320
KGGCILCGYL
330
KLMPMFIMVM
340
PGMISRILYT
350
EKIACVVPSE
360
CEKYCGTKVG
370
CTNIAYPTLV
380
VELMPNGLRG
390
LMLSVMLASL
400
MSSLTSIFNS
410
ASTLFTMDIY
420
AKVRKRASEK
430
ELMIAGRLFI
440
LVLIGISIAW
450
VPIVQSAQSG
460
QLFDYIQSIT
470
SYLGPPIAAV
480
FLLAIFWKRV
490
NEPGAFWGLI
500
LGLLIGISRM
510
ITEFAYGTGS
520
CMEPSNCPTI
530
ICGVHYLYFA
540
IILFAISFIT
550
IVVISLLTKP
560
IPDVHLYRLC
570
WSLRNSKEER
580
IDLDAEEENI
590
QEGPKETIEI
600
ETQVPEKKKG
610
IFRRAYDLFC
620
GLEQHGAPKM
630
TEEEEKAMKM
640
KMTDTSEKPL
650
WRTVLNVNGI
660
ILVTVAVFCH
AYFA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0031526 |
brush border membrane |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0097708 |
intracellular vesicle |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0015151 |
alpha-glucoside transmembrane transporter activity |
| Molecular Function |
GO:0055056 |
D-glucose transmembrane transporter activity |
| Molecular Function |
GO:0005412 |
D-glucose:sodium symporter activity |
| Molecular Function |
GO:0015150 |
fucose transmembrane transporter activity |
| Molecular Function |
GO:0005354 |
galactose transmembrane transporter activity |
| Molecular Function |
GO:0015371 |
galactose:sodium symporter activity |
| Molecular Function |
GO:0005367 |
myo-inositol:sodium symporter activity |
| Molecular Function |
GO:0015146 |
pentose transmembrane transporter activity |
| Molecular Function |
GO:0005372 |
water transmembrane transporter activity |
| Biological Process |
GO:0000017 |
alpha-glucoside transport |
| Biological Process |
GO:0098708 |
D-glucose import across plasma membrane |
| Biological Process |
GO:1904659 |
D-glucose transmembrane transport |
| Biological Process |
GO:0015756 |
fucose transmembrane transport |
| Biological Process |
GO:0015757 |
galactose transmembrane transport |
| Biological Process |
GO:0001951 |
intestinal D-glucose absorption |
| Biological Process |
GO:0106001 |
intestinal hexose absorption |
| Biological Process |
GO:0015798 |
myo-inositol transport |
| Biological Process |
GO:0015750 |
pentose transmembrane transport |
| Biological Process |
GO:0035623 |
renal D-glucose absorption |
| Biological Process |
GO:0098719 |
sodium ion import across plasma membrane |
| Biological Process |
GO:0035377 |
transepithelial water transport |
| Biological Process |
GO:0150104 |
transport across blood-brain barrier |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.