Search Results

Overview

Uniprot IDP13929
Protein NameBeta-enolase
Gene NameENO3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 CKAGAAEKGVPLYRH
179 PVGASSFKEAMRIGA
193 AEVYHHLKGVIKAKY
275 ARHITGEKLGELYKS
28 EVDLHTAKGRFRAAV
334 RIAQAVEKKACNCLL
358 TESIQACKLAQSNGW
406 CRSERLAKYNQLMRI
420 IEEALGDKAIFAGRK
54 LELRDGDKGRYLGKG
60 DKGRYLGKGVLKAVE
80 LGPALLQKKLSVVDQ
81 GPALLQKKLSVVDQE
89 LSVVDQEKVDKFMIE

Function

Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Appears to have a function in striated muscle development and regeneration

Protein Sequence

10 MAMQKIFARE 20 ILDSRGNPTV 30 EVDLHTAKGR 40 FRAAVPSGAS 50 TGIYEALELR 60 DGDKGRYLGK 70 GVLKAVENIN 80 NTLGPALLQK 90 KLSVVDQEKV 100 DKFMIELDGT 110 ENKSKFGANA 120 ILGVSLAVCK 130 AGAAEKGVPL 140 YRHIADLAGN 150 PDLILPVPAF 160 NVINGGSHAG 170 NKLAMQEFMI 180 LPVGASSFKE 190 AMRIGAEVYH 200 HLKGVIKAKY 210 GKDATNVGDE 220 GGFAPNILEN 230 NEALELLKTA 240 IQAAGYPDKV 250 VIGMDVAASE 260 FYRNGKYDLD 270 FKSPDDPARH 280 ITGEKLGELY 290 KSFIKNYPVV 300 SIEDPFDQDD 310 WATWTSFLSG 320 VNIQIVGDDL 330 TVTNPKRIAQ 340 AVEKKACNCL 350 LLKVNQIGSV 360 TESIQACKLA 370 QSNGWGVMVS 380 HRSGETEDTF 390 IADLVVGLCT 400 GQIKTGAPCR 410 SERLAKYNQL 420 MRIEEALGDK 430 AIFAGRKFRN PKAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016020 membrane
Cellular Component GO:0000015 phosphopyruvate hydratase complex
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004634 phosphopyruvate hydratase activity
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006096 glycolytic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.