Search Results
Overview
| Uniprot ID | P13984 |
|---|---|
| Protein Name | General transcription factor IIF subunit 2 |
| Gene Name | GTF2F2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | LQIEESSKPVRLSQQ |
| 147 | RLSQQLDKVVTTNYK |
| 154 | KVVTTNYKPVANHQY |
| 226 | EIGVQNVKGIHKNTW |
| 25 | VWLVKVPKYLSQQWA |
| 33 | YLSQQWAKASGRGEV |
Function
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB
Protein Sequence
10
MAERGELDLT
20
GAKQNTGVWL
30
VKVPKYLSQQ
40
WAKASGRGEV
50
GKLRIAKTQG
60
RTEVSFTLNE
70
DLANIHDIGG
80
KPASVSAPRE
90
HPFVLQSVGG
100
QTLTVFTESS
110
SDKLSLEGIV
120
VQRAECRPAA
130
SENYMRLKRL
140
QIEESSKPVR
150
LSQQLDKVVT
160
TNYKPVANHQ
170
YNIEYERKKK
180
EDGKRARADK
190
QHVLDMLFSA
200
FEKHQYYNLK
210
DLVDITKQPV
220
VYLKEILKEI
230
GVQNVKGIHK
240
NTWELKPEYR
HYQGEEKSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005674 | transcription factor TFIIF complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0016251 | RNA polymerase II general transcription initiation factor activity |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.