Search Results
Overview
| Uniprot ID | P13987 |
|---|---|
| Protein Name | CD59 glycoprotein |
| Gene Name | CD59 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 90 | ELTYYCCKKDLCNFN |
| 91 | LTYYCCKKDLCNFNE |
Function
Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035579 | specific granule membrane |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Cellular Component | GO:0030133 | transport vesicle |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0001848 | complement binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0001971 | negative regulation of activation of membrane attack complex |
| Biological Process | GO:0045916 | negative regulation of complement activation |
| Biological Process | GO:1903660 | negative regulation of complement-dependent cytotoxicity |
| Biological Process | GO:0030449 | regulation of complement activation |
| Biological Process | GO:1903659 | regulation of complement-dependent cytotoxicity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.