Search Results
Overview
| Uniprot ID | P13995 |
|---|---|
| Protein Name | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
| Gene Name | MTHFD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 329 | KNTIIAAKKVLRLEE |
Function
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency
Protein Sequence
10
MAATSLMSAL
20
AARLLQPAHS
30
CSLRLRPFHL
40
AAVRNEAVVI
50
SGRKLAQQIK
60
QEVRQEVEEW
70
VASGNKRPHL
80
SVILVGENPA
90
SHSYVLNKTR
100
AAAVVGINSE
110
TIMKPASISE
120
EELLNLINKL
130
NNDDNVDGLL
140
VQLPLPEHID
150
ERRICNAVSP
160
DKDVDGFHVI
170
NVGRMCLDQY
180
SMLPATPWGV
190
WEIIKRTGIP
200
TLGKNVVVAG
210
RSKNVGMPIA
220
MLLHTDGAHE
230
RPGGDATVTI
240
SHRYTPKEQL
250
KKHTILADIV
260
ISAAGIPNLI
270
TADMIKEGAA
280
VIDVGINRVH
290
DPVTAKPKLV
300
GDVDFEGVRQ
310
KAGYITPVPG
320
GVGPMTVAML
330
MKNTIIAAKK
340
VLRLEEREVL
350
KSKELGVATN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity |
| Molecular Function | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| Molecular Function | GO:0042301 | phosphate ion binding |
| Biological Process | GO:0046655 | folic acid metabolic process |
| Biological Process | GO:0015943 | formate biosynthetic process |
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
| Biological Process | GO:0046653 | tetrahydrofolate metabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.