Search Results
Overview
| Uniprot ID | P14136 |
|---|---|
| Protein Name | Glial fibrillary acidic protein |
| Gene Name | GFAP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | LRAKEPTKLADVYQA |
| 154 | DLATVRQKLQDETNL |
| 189 | ARLDLERKIESLEEE |
| 202 | EEIRFLRKIHEEEVR |
| 228 | HVELDVAKPDLTAAL |
| 236 | PDLTAALKEIRTQYE |
| 260 | AEEWYRSKFADLTDA |
| 397 | RETSLDTKSVSEGHL |
| 405 | SVSEGHLKRNIVVKT |
| 411 | LKRNIVVKTVEMRDG |
| 63 | GALNAGFKETRASER |
| 86 | RFASYIEKVRFLEQQ |
| 95 | RFLEQQNKALAAELN |
Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells
Protein Sequence
10
MERRRITSAA
20
RRSYVSSGEM
30
MVGGLAPGRR
40
LGPGTRLSLA
50
RMPPPLPTRV
60
DFSLAGALNA
70
GFKETRASER
80
AEMMELNDRF
90
ASYIEKVRFL
100
EQQNKALAAE
110
LNQLRAKEPT
120
KLADVYQAEL
130
RELRLRLDQL
140
TANSARLEVE
150
RDNLAQDLAT
160
VRQKLQDETN
170
LRLEAENNLA
180
AYRQEADEAT
190
LARLDLERKI
200
ESLEEEIRFL
210
RKIHEEEVRE
220
LQEQLARQQV
230
HVELDVAKPD
240
LTAALKEIRT
250
QYEAMASSNM
260
HEAEEWYRSK
270
FADLTDAAAR
280
NAELLRQAKH
290
EANDYRRQLQ
300
SLTCDLESLR
310
GTNESLERQM
320
REQEERHVRE
330
AASYQEALAR
340
LEEEGQSLKD
350
EMARHLQEYQ
360
DLLNVKLALD
370
IEIATYRKLL
380
EGEENRITIP
390
VQTFSNLQIR
400
ETSLDTKSVS
410
EGHLKRNIVV
420
KTVEMRDGEV
430
IKESKQEHKD
VM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097450 | astrocyte end-foot |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098574 | cytoplasmic side of lysosomal membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045111 | intermediate filament cytoskeleton |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0048484 | enteric nervous system development |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0001755 | neural crest cell migration |
| Biological Process | GO:0060252 | positive regulation of glial cell proliferation |
| Biological Process | GO:1904714 | regulation of chaperone-mediated autophagy |
| Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
| Biological Process | GO:0045471 | response to ethanol |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.