Search Results
Overview
| Uniprot ID | P14152 |
|---|---|
| Protein Name | Malate dehydrogenase, cytoplasmic |
| Gene Name | Mdh1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | KANVKIFKSQGTALE |
| 118 | SQGTALEKYAKKSVK |
| 199 | YPDVNHAKVKLQGKE |
| 205 | AKVKLQGKEVGVYEA |
| 236 | QRGAAVIKARKLSSA |
| 239 | AAVIKARKLSSAMSA |
| 312 | INDFSREKMDLTAKE |
| 318 | EKMDLTAKELTEEKE |
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)
Protein Sequence
10
MSEPIRVLVT
20
GAAGQIAYSL
30
LYSIGNGSVF
40
GKDQPIILVL
50
LDITPMMGVL
60
DGVLMELQDC
70
ALPLLQDVIA
80
TDKEEIAFKD
90
LDVAVLVGSM
100
PRREGMERKD
110
LLKANVKIFK
120
SQGTALEKYA
130
KKSVKVIVVG
140
NPANTNCLTA
150
SKSAPSIPKE
160
NFSCLTRLDH
170
NRAKSQIALK
180
LGVTADDVKN
190
VIIWGNHSST
200
QYPDVNHAKV
210
KLQGKEVGVY
220
EALKDDSWLK
230
GEFITTVQQR
240
GAAVIKARKL
250
SSAMSAAKAI
260
ADHIRDIWFG
270
TPEGEFVSMG
280
VISDGNSYGV
290
PDDLLYSFPV
300
VIKNKTWKFV
310
EGLPINDFSR
320
EKMDLTAKEL
330
TEEKETAFEF
LSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Molecular Function | GO:0047995 | (2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity |
| Molecular Function | GO:0030060 | L-malate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0016615 | malate dehydrogenase activity |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.