Search Results
Overview
| Uniprot ID | P14174 |
|---|---|
| Protein Name | Macrophage migration inhibitory factor |
| Gene Name | MIF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 78 | AQNRSYSKLLCGLLA |
Function
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed:15908412, PubMed:17443469, PubMed:23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (PubMed:15908412, PubMed:17443469, PubMed:23776208). Counteracts the anti-inflammatory activity of glucocorticoids (PubMed:15908412, PubMed:17443469, PubMed:23776208). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:11439086, PubMed:17526494). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:11439086, PubMed:17526494)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0042056 | chemoattractant activity |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0005126 | cytokine receptor binding |
| Molecular Function | GO:0004167 | dopachrome isomerase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050178 | phenylpyruvate tautomerase activity |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:2000773 | negative regulation of cellular senescence |
| Biological Process | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0010760 | negative regulation of macrophage chemotaxis |
| Biological Process | GO:0002906 | negative regulation of mature B cell apoptotic process |
| Biological Process | GO:0033033 | negative regulation of myeloid cell apoptotic process |
| Biological Process | GO:0051248 | negative regulation of protein metabolic process |
| Biological Process | GO:0090238 | positive regulation of arachidonate secretion |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000343 | positive regulation of chemokine (C-X-C motif) ligand 2 production |
| Biological Process | GO:0001819 | positive regulation of cytokine production |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:0061081 | positive regulation of myeloid leukocyte cytokine production involved in immune response |
| Biological Process | GO:0042327 | positive regulation of phosphorylation |
| Biological Process | GO:0061078 | positive regulation of prostaglandin secretion involved in immune response |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0070207 | protein homotrimerization |
| Biological Process | GO:0043030 | regulation of macrophage activation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.